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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Immunocytochemistry (ICC)||10 Antibodies|
|Immunofluorescence (IF)||23 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||34 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||3 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||21 Antibodies|
|Immunoprecipitation (IP)||8 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Western Blotting (WB)||112 Antibodies|
|Antigen||Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) Antibodies|
|Epitope||AA 1-111 Alternatives|
|Conjugate||This Caspase 10 antibody is un-conjugated Alternatives|
|5 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 10 AntibodyTarget Details Caspase 10 Application Details Handling References for anti-Caspase 10 Antibody (ABIN393206) Images
|Specificity||CASP10 (NP_116756, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Purification||This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||CASP10 (NP_116756, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
Target Details Caspase 10Product Details anti-Caspase 10 Antibody Application Details Handling References for anti-Caspase 10 Antibody (ABIN393206) Images back to top
|Alternative Name||CASP10 (CASP10 Antibody Abstract)|
|Background||Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1|
|Molecular Weight||58951 DA|
|Research Area||Apoptosis/Necrosis, Cell Structure|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-Caspase 10 Antibody Target Details Caspase 10 Handling References for anti-Caspase 10 Antibody (ABIN393206) Images back to top
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml|
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 10 Antibody Target Details Caspase 10 Application Details References for anti-Caspase 10 Antibody (ABIN393206) Images back to top
|Buffer||PBS with 0.09% (w/v) sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Expiry Date||6 months|
References for anti-Caspase 10 Antibody (ABIN393206)Product Details anti-Caspase 10 Antibody Target Details Caspase 10 Application Details Handling Images back to top
Lee, Choi, Choi et al.: "Polymorphisms in the caspase genes and the risk of lung cancer." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 5, Issue 8, pp. 1152-8, 2010 (PubMed).
Ho-Pun-Cheung, Assenat, Bascoul-Mollevi et al.: "A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 437-43, 2011 (PubMed).
Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).
Kim, Park, Kim et al.: "Mutational analysis of caspase genes in prostate carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 118, Issue 4, pp. 308-12, 2010 (PubMed).
Oh, Kim, Ahn et al.: "Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas." in: Pathology, Vol. 42, Issue 1, pp. 73-6, 2009 (PubMed).
ImagesProduct Details anti-Caspase 10 Antibody Target Details Caspase 10 Application Details Handling References for anti-Caspase 10 Antibody (ABIN393206) back to top