Caspase-10 is involved in the activation cascade of caspases responsible for apoptosis execution. Caspase-10 is recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner, and participates in the granzyme B apoptotic pathways. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Defects in caspase-10 are a cause of familial non-Hodgkin lymphoma (NHL). NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
Each vial contains 0.1 mg IgG in 0.1 mL of PBS pH7.4, 1% BSA with 0.09% sodium azide.
Precaution of Use
Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.