anti-Human Caspase 2 antibody for Immunofluorescence

Recommended Caspase 2 Antibody (supplied by: Log in to see )

Antigen
Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies
  • xCaspase-2
  • Caspase-2
  • ICH-1
  • Nedd2
  • CASP-2
  • ICH1
  • NEDD-2
  • NEDD2
  • PPP1R57
  • ICH-1L/1S
  • ICH1L1S
  • caspase-2-like
  • caspase-2
  • caspase 2
  • caspase 2, apoptosis-related cysteine peptidase
  • LOC100050611
  • xCaspase-2
  • CpipJ_CPIJ008254
  • Casp2
  • LOC100101590
  • CASP2
  • LOC100521118
Epitope
AA 225-401
27
21
14
9
7
5
5
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
209
90
69
10
8
2
2
2
2
2
1
1
1
1
1
1
Host
Mouse
156
50
13
Clonality
Monoclonal
Conjugate
This Caspase 2 antibody is un-conjugated
6
6
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
179
98
47
35
17
13
13
12
12
4
4
4
2
1
Options
Supplier
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Catalog No. ABIN968324
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.326117 ABIN968323 IF WB Mouse IgG1 AA 225-401 Log in to see 35-Caspase-2-ICH 5
12.326117 ABIN4288067 ICC IF IHC IHC (p) Rabbit Log in to see Polyclonal
12.326117 ABIN514019 IF ELISA WB Mouse IgG2a kappa AA 121-220, partial Log in to see 1C11
1 ABIN303201 IF IHC (p) WB Rabbit N-Term Log in to see Polyclonal
1 ABIN5554658 EIA IF WB Rabbit IgG N-Term Log in to see Polyclonal
1 ABIN187543 FACS IHC (fro) IF Rat IgG2a Log in to see 10C6
1 ABIN4288071 ELISA ICC IF WB Rabbit N-Term Log in to see Polyclonal
1 ABIN4957588 ELISA ICC IF WB Rabbit N-Term Log in to see Polyclonal
1 ABIN1827514 IF ELISA WB Mouse IgG2a, kappa AA 121-220 Log in to see 1C11
1 ABIN4903136 FACS ICC IF IHC WB Rabbit IgG Log in to see
1 ABIN1172666 ICC IF IHC WB FITC Rabbit IgG Log in to see Polyclonal
1 ABIN2218759 IF ELISA WB Mouse IgG2a kappa AA 121-220 Log in to see 1C11
1 ABIN2772048 IF ELISA WB Mouse IgG2a, kappa Log in to see

Top referenced anti-Caspase 2 antibody for Immunofluorescence

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Application / Reactivity Human
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Flow Cytometry (FACS) 12 Antibodies
Immunochromatography (IC) 4 Antibodies
Immunocytochemistry (ICC) 16 Antibodies
Immunofluorescence (IF) 14 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies
Immunohistochemistry (IHC) 45 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 34 Antibodies
Immunoprecipitation (IP) 11 Antibodies
Western Blotting (WB) 170 Antibodies

General

Antigen Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies
Epitope AA 225-401
(27), (21), (14), (9), (7), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(209), (90), (69), (10), (8), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Mouse
(156), (50), (13)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Caspase 2 antibody is un-conjugated
(6), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Western Blotting (WB)
(179), (98), (47), (35), (17), (13), (13), (12), (12), (4), (4), (4), (2), (1)
Pubmed 5 references available
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Product Details anti-Caspase 2 Antibody

Target Details Caspase 2 Application Details Handling ProductDetails: References for anti-Caspase 2 antibody (ABIN968324) Images
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human ICH-1L aa. 225-401
Clone 35-Caspase-2-ICH
Isotype IgG1

Target Details Caspase 2

Product Details anti-Caspase 2 Antibody Application Details Handling ProductDetails: References for anti-Caspase 2 antibody (ABIN968324) Images back to top
Antigen
Alternative Name Caspase-2 (CASP2 Antibody Abstract)
Background Caspase-2/ICH-1 is related to the C. elegans cell death gene product CED-3 and its mammalian homologue interleukin-1beta-converting enzyme (ICE). Caspase-2 /ICH-1 was identified from a mouse cDNA library and originally termed NEDD-2. The NEDD-2 mRNA was found to be expressed during early mouse embryonic brain development and subsequently down-regulated in adult neuronal tissue. With the identification of the human NEDD-2 gene, the murine gene was renamed Ich-1 to symbolize Ice and ced-3 homology. Caspase-2/ICH-1 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as Caspase-2 long, or ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named Caspase-2 short, or ICH-1S. Overexpression of ICH-1L induces apoptosis, while over-expression of Ich-1S suppresses Rat-1 cell death induced by serum deprivation. Thus, it appears that Caspase-2/ICH-1 plays an important dual role in programmed cell death.
Synonyms: ICH-1L
Molecular Weight 48 kDa
Research Area Apoptosis/Necrosis, Cancer, Autophagy
Pathways Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway

Application Details

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Handling ProductDetails: References for anti-Caspase 2 antibody (ABIN968324) Images back to top
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details ProductDetails: References for anti-Caspase 2 antibody (ABIN968324) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.

ProductDetails: References for anti-Caspase 2 antibody (ABIN968324)

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling Images back to top
Product cited in:

Guo, Srinivasula, Druilhe, Fernandes-Alnemri, Alnemri: "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13430-7, 2002

Li, Chen, Sinogeeva, Gorospe, Wersto, Chrest, Barnes, Liu: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, 2002

Mancini, Machamer, Roy, Nicholson, Thornberry, Casciola-Rosen, Rosen: "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis." in: The Journal of cell biology, Vol. 149, Issue 3, pp. 603-12, 2000

Shibata, Hisahara, Hara, Yamawaki, Fukuuchi, Yuan, Okano, Miura: "Caspases determine the vulnerability of oligodendrocytes in the ischemic brain." in: The Journal of clinical investigation, Vol. 106, Issue 5, pp. 643-53, 2000

Wang, Miura, Bergeron, Zhu, Yuan: "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death." in: Cell, Vol. 78, Issue 5, pp. 739-50, 1994

Images

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling ProductDetails: References for anti-Caspase 2 antibody (ABIN968324) back to top
Supplier Images
Western Blotting (WB) image for anti-Caspase 2 antibody (Caspase 2, Apoptosis-Related Cysteine Peptidase) (AA 225-401) (ABIN968324) Western blot analysis of Caspase-2 on Jurkat cell lysate. Lane 1: 1:1000, lane 2: 1:2...
Immunofluorescence (IF) image for anti-Caspase 2 antibody (Caspase 2, Apoptosis-Related Cysteine Peptidase) (AA 225-401) (ABIN968324) Immunofluorescent staining of FHS cells.
 image for anti-Caspase 2 antibody (Caspase 2, Apoptosis-Related Cysteine Peptidase) (AA 225-401) (ABIN968324) anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 225-401) antibody (Image 3)