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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||15 Antibodies||74 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||3 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies||10 Antibodies|
|Immunocytochemistry (ICC)||6 Antibodies||10 Antibodies|
|Immunofluorescence (IF)||3 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||6 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||3 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||12 Antibodies|
|Immunoprecipitation (IP)||4 Antibodies|
|Western Blotting (WB)||45 Antibodies|
|BioImaging (BI)||1 Antibodies|
|Immunochromatography (IC)||4 Antibodies|
|Antigen||Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This Caspase 2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 2 AntibodyTarget Details Caspase 2 Application Details Handling References for anti-Caspase 2 Antibody (ABIN499559) Images
|Specificity||Caspase-2 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-2.|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||Murine Casp-2 / ICH-1 / Nedd2 (N-Terminus) Peptide|
Target Details Caspase 2Product Details anti-Caspase 2 Antibody Application Details Handling References for anti-Caspase 2 Antibody (ABIN499559) Images back to top
|Alternative Name||Caspase-2 (CASP2 Antibody Abstract)|
|Background||Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis (5). Caspase-2 has two major isoforms, overexpression on the long form results in apoptosis while that of the short form suppresses cell death (6).Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2|
|Research Area||Apoptosis/Necrosis, Cancer, Autophagy|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Handling References for anti-Caspase 2 Antibody (ABIN499559) Images back to top
ELISA. Western Blot: Caspase-2 antibody can be used for the detection of caspase-2 at 1 μg/mL. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details References for anti-Caspase 2 Antibody (ABIN499559) Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
References for anti-Caspase 2 Antibody (ABIN499559)Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling Images back to top
Zhivotovsky, Orrenius: "Caspase-2 function in response to DNA damage." in: Biochemical and biophysical research communications, Vol. 331, Issue 3, pp. 859-67, 2005 (PubMed).
Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).
Gracie, Robertson, McInnes: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, 2003 (PubMed).
Kuida, Lippke, Ku et al.: "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 267, Issue 5206, pp. 2000-3, 1995 (PubMed).
ImagesProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling References for anti-Caspase 2 Antibody (ABIN499559) back to top