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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||26 Antibodies||126 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||5 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies||2 Antibodies|
|Immunochromatography (IC)||1 Antibodies||6 Antibodies|
|Immunocytochemistry (ICC)||4 Antibodies||21 Antibodies|
|Immunofluorescence (IF)||13 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies|
|Immunohistochemistry (IHC)||34 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||18 Antibodies|
|Immunoprecipitation (IP)||4 Antibodies|
|Western Blotting (WB)||55 Antibodies|
|Antigen||Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This Caspase 6 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 6 AntibodyTarget Details Caspase 6 Application Details Handling References for anti-Caspase 6 Antibody (ABIN356823) Images
|Specificity||This antibody is specific to Caspase-6 (C-term).|
|Purification||Protein A Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CASP6.|
Target Details Caspase 6Product Details anti-Caspase 6 Antibody Application Details Handling References for anti-Caspase 6 Antibody (ABIN356823) Images back to top
|Alternative Name||Caspase-6 (CASP6 Antibody Abstract)|
|Background||CASP6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2|
|Gene ID||839, 9606|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-Caspase 6 Antibody Target Details Caspase 6 Handling References for anti-Caspase 6 Antibody (ABIN356823) Images back to top
ELISA: 1/1,000. Western blot: 1/50-1/100. Immunohistochemistry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details References for anti-Caspase 6 Antibody (ABIN356823) Images back to top
|Buffer||PBS containing 0.09 % (W/V) Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-Caspase 6 Antibody (ABIN356823)Product Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details Handling Images back to top
Schmeck, Gross, NGuessan et al.: "Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium." in: Infection and immunity, Vol. 72, Issue 9, pp. 4940-7, 2004 (PubMed).
Méndez, Salas-Ocampo, Arias: "Caspases mediate processing of the capsid precursor and cell release of human astroviruses." in: Journal of virology, Vol. 78, Issue 16, pp. 8601-8, 2004 (PubMed).
Sordet, Rébé, Dubrez-Daloz et al.: "Intracellular redistribution of procaspases during TPA-induced differentiation of U937 human leukemic cells." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 16, Issue 8, pp. 1569-70, 2002 (PubMed).
MacLachlan, El-Deiry: "Apoptotic threshold is lowered by p53 transactivation of caspase-6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 14, pp. 9492-7, 2002 (PubMed).
LeBlanc, Liu, Goodyer et al.: "Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 274, Issue 33, pp. 23426-36, 1999 (PubMed).
ImagesProduct Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details Handling References for anti-Caspase 6 Antibody (ABIN356823) back to top