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anti-Human DIABLO antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended DIABLO Antibody (supplied by: Log in to see )

Antigen
Second Mitochondria-Derived Activator of Caspase (DIABLO) Antibodies
  • 0610041G12Rik
  • 1700006L01Rik
  • AU040403
  • DBO
  • DFNA64
  • diablo-s
  • SMAC
  • Smac
  • smac
  • smac3
  • XSmac
Epitope
AA 177-211
32
16
13
11
8
6
4
4
4
3
3
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
138
54
34
4
4
3
2
1
1
Host
Rabbit
117
30
8
1
Clonality
Polyclonal
Conjugate
This DIABLO antibody is un-conjugated
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
144
58
57
31
23
11
8
6
4
4
2
2
2
1
1
1
1
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Catalog No. ABIN674619
$ 269.50
Plus shipping costs $45.00

Top referenced anti-DIABLO antibody for Immunofluorescence (Paraffin-embedded Sections)

Similar anti-DIABLO Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 16 Antibodies 24 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 1 Antibodies
Flow Cytometry (FACS) 1 Antibodies 6 Antibodies
Immunocytochemistry (ICC) 3 Antibodies 6 Antibodies
Immunofluorescence (IF) 6 Antibodies 7 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies 1 Antibodies
Immunohistochemistry (IHC) 23 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 10 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Western Blotting (WB) 36 Antibodies
Immunochromatography (IC) 3 Antibodies

General

Antigen Second Mitochondria-Derived Activator of Caspase (DIABLO) Antibodies
Epitope AA 177-211
(32), (16), (13), (11), (8), (6), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(138), (54), (34), (4), (4), (3), (2), (1), (1)
Host Rabbit
(117), (30), (8), (1)
Clonality
Polyclonal
Conjugate This DIABLO antibody is un-conjugated
(1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(144), (58), (57), (31), (23), (11), (8), (6), (4), (4), (2), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-DIABLO Antibody

Target Details DIABLO Application Details Handling References for anti-DIABLO Antibody (ABIN674619) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Smac
Isotype IgG

Target Details DIABLO

Product Details anti-DIABLO Antibody Application Details Handling References for anti-DIABLO Antibody (ABIN674619) Images back to top
Antigen
Alternative Name Smac/Diablo (DIABLO Antibody Abstract)
Background

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Subcellular location: Helical, Mitochondrion


Synonyms: SMAC, DFNA64, Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, DIABLO
Gene ID 56616
UniProt Q9NR28
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-DIABLO Antibody Target Details DIABLO Handling References for anti-DIABLO Antibody (ABIN674619) Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-DIABLO Antibody Target Details DIABLO Application Details References for anti-DIABLO Antibody (ABIN674619) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-DIABLO Antibody (ABIN674619)

Product Details anti-DIABLO Antibody Target Details DIABLO Application Details Handling Images back to top
Product cited in:

Liu, Chen, Li, Wang, Cheng: "Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts." in: International journal of molecular medicine, Vol. 32, Issue 3, pp. 615-22, 2013

Images

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Supplier Images
Immunohistochemistry (IHC) image for anti-DIABLO antibody (Second Mitochondria-Derived Activator of Caspase) (AA 177-211) (ABIN674619) Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti Smac/DI...
SDS-PAGE (SDS) image for anti-DIABLO antibody (Second Mitochondria-Derived Activator of Caspase) (AA 177-211) (ABIN674619) Lane 1: rat kidney lysates Lane 2: rat brain lysates probed with Anti AVPR2 Polyclona...
Immunohistochemistry (IHC) image for anti-DIABLO antibody (Second Mitochondria-Derived Activator of Caspase) (AA 177-211) (ABIN674619) Gastric Cancer Cells labeled with Anti-Smac/DIABLO Polyclonal Antibody, Unconjugated ...