anti-Human TNFRSF10D antibody for Neutralization

Recommended TNFRSF10D Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) Antibodies
  • TNFRSF10D
  • CD264
  • DCR2
  • TRAIL-R4
  • TRAILR4
  • TRUNDD
  • tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
  • TNFRSF10D
Epitope
AA 56-211
33
23
13
12
11
10
10
9
9
6
3
3
3
2
1
1
1
1
1
1
Reactivity
Human
225
9
6
2
Host
Mouse
125
97
3
Clonality
Monoclonal
Conjugate
This TNFRSF10D antibody is un-conjugated
16
14
9
9
7
6
6
6
5
4
3
3
3
3
3
3
3
3
3
3
3
3
2
Application
Cytometry by Time of Flight (CyTOF), ELISA (Capture), Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
112
99
58
28
11
10
8
7
7
6
5
3
2
1
1
1
1
Supplier
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Catalog No. ABIN4900417
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
38.248745 ABIN4900418 CyTOF FACS IHC Neut WB Goat IgG AA 56-211 Log in to see Polyclonal 6
1 ABIN5646465 CyTOF ELISA (Capture) FACS Neut WB Mouse IgG1 AA 56-211 Log in to see 104918
1 ABIN5634420 CyTOF FACS IHC Neut WB Goat IgG AA 56-211 Log in to see Polyclonal
1 ABIN4249000 BP Neut WB Mouse IgG1 Log in to see MM0579-6G9
1 ABIN4249003 BP Neut Mouse IgG1 Log in to see 104917
1 ABIN4249004 BP Neut Mouse IgG1 Log in to see 104917
1 ABIN4249005 BP Neut Mouse IgG1 Log in to see 104913
1 ABIN4249006 BP Neut Mouse IgG1 Log in to see 104913
1 ABIN4249001 BP Neut Mouse IgG1 Log in to see 102926
1 ABIN4249002 BP Neut Mouse IgG1 Log in to see 102926
1 ABIN1983463 Neut WB Mouse IgG1 AA 56-211 Log in to see MM0579-6G9

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) Antibodies
Epitope AA 56-211
(33), (23), (13), (12), (11), (10), (10), (9), (9), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human
(225), (9), (6), (2)
Host Mouse
(125), (97), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF10D antibody is un-conjugated
(16), (14), (9), (9), (7), (6), (6), (6), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2)
Application Cytometry by Time of Flight (CyTOF), ELISA (Capture), Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
(112), (99), (58), (28), (11), (10), (8), (7), (7), (6), (5), (3), (2), (1), (1), (1), (1)
Pubmed 12 references available
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Product Details anti-TNFRSF10D Antibody

Target Details TNFRSF10D Application Details Handling References for anti-TNFRSF10D antibody (ABIN4900417) Images
Specificity Detects human TRAIL R4/TNFRSF10D in ELISAs and Western blots. In sandwich immunoassays, less than 5 % cross-reactivity with recombinant human (rh) TRAIL R1, rhTRAIL R2, TRAIL R3, rhTRAIL, rhTNF-alpha , and rhTNF-beta is observed.
Purification Protein A or G purified from ascites
Sterility 0.2 μm filtered
Endotoxin Level <0.10 EU per 1 μg of the antibody by the LAL method.
Immunogen Mouse myeloma cell line NS0-derived recombinant human TRAIL R4/TNFRSF10D, Ala56-His211, Accession # Q9UBN6
Clone 104918
Isotype IgG1

Target Details TNFRSF10D

Product Details anti-TNFRSF10D Antibody Application Details Handling References for anti-TNFRSF10D antibody (ABIN4900417) Images back to top
Antigen
Alternative Name TRAIL R4/TNFRSF10D (TNFRSF10D Antibody Abstract)
Background Alternative Names: CD264, CD264 antigen, DcR2, DCR2decoy with truncated death domain, Decoy receptor 2, TNF receptor-related receptor for TRAIL, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAILR4, TRAIL-R4, TRAILR4TRAIL receptor 4, TRUNDDTRAIL receptor with a truncated death domain, tumor necrosis factor receptor superfamily member 10D, tumor necrosis factor receptor superfamily, member 10d, decoy with truncateddeath domain
Gene ID 8793
UniProt Q9UBN6
Pathways Apoptosis

Application Details

Product Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Handling References for anti-TNFRSF10D antibody (ABIN4900417) Images back to top
Application Notes Western Blot 1 μg/mL
Flow Cytometry 2.5 μg/10^6 cells
Neutralization 0.04-0.2 μg/mL
CyTOF-ready
ELISA Capture (Matched Antibody Pair) 2-8 μg/mL
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Application Details References for anti-TNFRSF10D antibody (ABIN4900417) Images back to top
Reconstitution Reconstitute at 0.5 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Expiry Date 12 months

References for anti-TNFRSF10D antibody (ABIN4900417)

Product Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Application Details Handling Images back to top
Product cited in:

Neumann, Hasenauer, Pollak, Scheurich: "Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes." in: The Journal of biological chemistry, Vol. 289, Issue 23, pp. 16576-87, 2014

Moniri, Sun, Rayat, Dai, Ao, He, Verchere, Dai, Warnock: "TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells." in: Cancer gene therapy, Vol. 19, Issue 9, pp. 652-8, 2012 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Stary, Klein, Kohlhofer, Koszik, Scherzer, Müllauer, Quendler, Kohrgruber, Stingl: "Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients." in: Blood, Vol. 114, Issue 18, pp. 3854-63, 2009 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Zauli, Rimondi, Celeghini, Milani, Secchiero: "Dexamethasone counteracts the anti-osteoclastic, but not the anti-leukemic, activity of TNF-related apoptosis inducing ligand (TRAIL)." in: Journal of cellular physiology, Vol. 222, Issue 2, pp. 357-64, 2009 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Barbarotto, Corallini, Rimondi, Fadda, Mischiati, Grill, Vaccarezza, Celeghini: "Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells." in: Journal of cellular biochemistry, Vol. 104, Issue 2, pp. 595-605, 2008 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Secchiero, Melloni, Corallini, Beltrami, Alviano, Milani, DAurizio, di Iasio, Cesselli, Bagnara, Zauli: "Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 11, pp. 2955-63, 2008 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Toscano, Fajoui, Gay, Lalaoui, Parmentier, Chayvialle, Scoazec, Micheau, Abello, Saurin: "P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells." in: Oncogene, Vol. 27, Issue 30, pp. 4161-71, 2008 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Weinmann, Wischhusen, Demma, Naumann, Roth, Dasmahapatra, Weller: "A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis." in: Cell death and differentiation, Vol. 15, Issue 4, pp. 718-29, 2008 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Shankar, Chen, Ganapathy, Singh, Srivastava: "Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms." in: Molecular cancer therapeutics, Vol. 7, Issue 8, pp. 2328-38, 2008 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Braun, Fecker, Schwarz, Walden, Assaf, Dürkop, Sterry, Eberle: "Blockade of death receptor-mediated pathways early in the signaling cascade coincides with distinct apoptosis resistance in cutaneous T-cell lymphoma cells." in: The Journal of investigative dermatology, Vol. 127, Issue 10, pp. 2425-37, 2007 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Locklin, Federici, Espina, Hulley, Russell, Edwards: "Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis." in: Molecular cancer therapeutics, Vol. 6, Issue 12 Pt 1, pp. 3219-28, 2007 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Singh, Shankar, Srivastava: "HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma." in: Oncogene, Vol. 24, Issue 29, pp. 4609-23, 2005 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Images

Product Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Application Details Handling References for anti-TNFRSF10D antibody (ABIN4900417) back to top
Supplier Images
Neutralization (Neut) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 56-211) antibody (ABIN4900417) TRAIL R4/TNFRSF10D Inhibition of TRAIL/TNFSF10-induced Cytotoxicity and Neutralizatio...
Neutralization (Neut) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 56-211) antibody (ABIN4900417) TRAIL R4/TNFRSF10D Inhibition of TRAIL/TNFSF10-induced Cytotoxicity and Neutralizatio...