Browse our anti-PLAT (PLAT) Antibodies

Full name:
anti-Plasminogen Activator, Tissue Antibodies (PLAT)
On www.antibodies-online.com are 324 Plasminogen Activator, Tissue (PLAT) Antibodies from 30 different suppliers available. Additionally we are shipping PLAT Kits (86) and PLAT Proteins (72) and many more products for this protein. A total of 497 PLAT products are currently listed.
Synonyms:
AU020998, AW212668, D8Ertd2e, PATISS, Plat, T-PA, tPA

Most Popular Reactivities for anti-PLAT (PLAT) Antibodies

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anti-Human PLAT Antibodies:

anti-Mouse (Murine) PLAT Antibodies:

anti-Rat (Rattus) PLAT Antibodies:

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Top referenced anti-PLAT Antibodies

  1. Human Polyclonal PLAT Primary Antibody for ELISA, IHC - ABIN4357455 : Gerenu, Martisova, Ferrero, Carracedo, Rantamäki, Ramirez, Gil-Bea: Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits. in Biochimica et biophysica acta 2017 (PubMed)

  2. Human Polyclonal PLAT Primary Antibody for IHC, IHC (p) - ABIN4357454 : Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011 (PubMed)

  3. Human Polyclonal PLAT Primary Antibody for IF (p), IHC (p) - ABIN731123 : Balaoing, Post, Liu, Minn, Grande-Allen: Age-related changes in aortic valve hemostatic protein regulation. in Arteriosclerosis, thrombosis, and vascular biology 2013 (PubMed)

  4. Human Polyclonal PLAT Primary Antibody for EIA, WB - ABIN453432 : de Vos, Ultsch, Kelley, Padmanabhan, Tulinsky, Westbrook, Kossiakoff: Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution. in Biochemistry 1992 (PubMed)

More Antibodies against PLAT Interaction Partners

Human Plasminogen Activator, Tissue (PLAT) interaction partners

  1. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.

  2. Data suggest that protein aggregates interact with tissue-type plasminogen activator and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).

  3. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.

  4. tPA is a ligand of the N-terminal domain of the obligatory GluN1 (show GRIN1 Antibodies) subunit of NMDAR (show GRIN1 Antibodies) acting as a modulator of their dynamic distribution at the neuronal surface and subsequent signaling.

  5. t-PA binds to Lys91 in the MBP (show MBL2 Antibodies) NH2-terminal region and PLGbinds to Lys122 in the MBP (show MBL2 Antibodies) COOH-terminal region. This proximity promotes the activation of Pg by t-PA.

  6. local accumulation of cortisol is a causative factor for amnion epithelial apoptosis via activation of tPA/plasmin (show PLG Antibodies) system toward the end of gestation. This may contribute to the ROM (show ROM1 Antibodies) at both term and preterm birth.

  7. We identified a homozygous null mutation in PLAT that abrogated t-PA level in patient cells. This is the first reported human knockout mutation of PLAT. The apparent association with hydranencephaly, diaphragmatic hernia and postnatal lethality requires further validation.

  8. Tissue plasminogen activator (t-PA) antigen is a marker of cardiovascular risk. Exercise interventions associated with weight loss reduce t-PA antigen. Endurance training per se reduces t-PA antigen in healthy overweight men.

  9. we reviewed current knowledge of mechanisms by which tPA can influence brain function in physiological and pathological conditions--REVIEW}

  10. This study examines the complexes of PAI-1 (show SERPINE1 Antibodies) with tissue-type and urokinase-type plasminogen activator (show PLAU Antibodies) and vitronectin (show VTN Antibodies) revealed by changes in the conformation and dynamics of the reactive center loop.

Mouse (Murine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.

  2. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.

  3. A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA).

  4. While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis.

  5. mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA

  6. administration of ADAMTS13 (show ADAMTS13 Antibodies) 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA (show RSPH1 Antibodies) patency and consequently reduced cerebral infarct sizes

  7. strategies contributing to promote either endogenous production of tPA or its associated EGFR (show EGFR Antibodies)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.

  8. Plasminogen (show PLG Antibodies) activation contributes to wound repair and suggest that adenosine A2A receptor (show ADORA2A Antibodies) activation promotes wound closure by a mechanism that depends on tPA.

  9. Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK (show PTK2 Antibodies), Rac-1, and NF-kappaB (show NFKB1 Antibodies).

  10. the protective effect of neuroserpin (show SERPINI1 Antibodies) maybe independent from its canonical interaction with a tissue-type plasminogen activator

Pig (Porcine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. The plasminogen/plasminogen (show PLG Antibodies) activator/plasmin (show PLG Antibodies) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.

  3. a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile

  4. ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP

Cow (Bovine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. The plasminogen/plasminogen (show PLG Antibodies) activator/plasmin (show PLG Antibodies) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Antibodies) production, consistent with a role in extracellular matrix remodeling during follicle growth

  3. These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (show MAPK8 Antibodies) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.

PLAT Antigen Profile

Antigen Summary

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PLAT

  • plasminogen activator, tissue (PLAT) antibody
  • plasminogen activator, tissue (plat) antibody
  • tissue-type plasminogen activator (tpa) antibody
  • plasminogen activator, tissue (Plat) antibody
  • AU020998 antibody
  • AW212668 antibody
  • D8Ertd2e antibody
  • PATISS antibody
  • Plat antibody
  • T-PA antibody
  • tPA antibody

Protein level used designations for PLAT

plasminogen activator, tissue , plasminogen activator, tissue type , tissue-type plasminogen activator , t-PA , t-plasminogen activator , tPA , tissue-type plasminogen activator-like , alteplase , reteplase , tissue plasminogen activator (t-PA) , tissue plasminogen activator , T-plasminogen activator

GENE ID SPECIES
374183 Gallus gallus
472748 Pan troglodytes
594962 Xenopus (Silurana) tropicalis
704475 Macaca mulatta
100049466 Oryzias latipes
100050239 Equus caballus
100173068 Pongo abelii
100391990 Callithrix jacchus
100542402 Meleagris gallopavo
100586515 Nomascus leucogenys
5327 Homo sapiens
18791 Mus musculus
25692 Rattus norvegicus
397121 Sus scrofa
100725281 Cavia porcellus
100009556 Oryctolagus cuniculus
281407 Bos taurus
482840 Canis lupus familiaris
426791 Gallus gallus
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