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Human SPARC ELISA Kit for Sandwich ELISA - ABIN366827
Beraudi, Montesi, Traina, Falcioni, Stea, Toni: Uncemented primary total hip arthroplasty, presentation of pain, and expression of osteonectin. in Artificial organs 2013
Mouse (Murine) SPARC ELISA Kit for Sandwich ELISA - ABIN415439
Galimov, Hartung, Trepp, Mader, Flück, Linke, Blüher, Christ, Krützfeldt: Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance. in Journal of molecular medicine (Berlin, Germany) 2015
Rat (Rattus) SPARC ELISA Kit for Sandwich ELISA - ABIN368276
Scuteri, Ravasi, Pasini, Bossi, Tredici: Mesenchymal stem cells support dorsal root ganglion neurons survival by inhibiting the metalloproteinase pathway. in Neuroscience 2010
these data identify a contributory role for DNA methylation (show HELLS ELISA Kits) in regulating sparc expression in zebrafish embryogenesis.
Results establish a role for an ECM (show MMRN1 ELISA Kits) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.
Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.
Sparc is directly required for normal otolith growth
SPARC plays a key role in influencing the spatial organization of the anterior segment, potentially via modulation of collagen properties, while Hevin is not likely to be involved.
An ADAMTS1 (show ADAMTS1 ELISA Kits) blocking antibody suppressed the SPARC-induced collagen I secretion, indicating that SPARC promoted collagen production directly through ADAMTS1 (show ADAMTS1 ELISA Kits) interaction. In conclusion, ADAMTS1 (show ADAMTS1 ELISA Kits) is an important mediator of SPARC-regulated cardiac aging.
SPARC appears to be an important modulator of the actin cytoskeleton, implicating maintenance of muscular function
resistivity measurements were taken on 22 mice, 11 wild-type and 11 sparc-/- (knock out for the protein SPARC: secreted protein acidic and rich in cysteine), bearing mammary carcinomas.
SPARC isoforms, acting on Adipose stromal cells through distinct mechanisms, have an additive effect in inducing ASC (show STS ELISA Kits) migration.
SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.
SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues.
Tumor-produced SPARC and VCAM1 (show VCAM1 ELISA Kits) are regulators of cancer extravasation.
The results of this study indicated that the loss of p53 (show TP53 ELISA Kits) by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance.
This work suggests that SPARC could affect anxiety-related behavior by modulating neuronal activity, and that depression-related behavior is dependent upon the adult expression of SPARC, which affects adult brain function.
SPARC can serve a dual function role as both predictor for prognosis and potentially biomarker for lymph node metastasis in resected pancreatic cancer patients.
that SPARC-mediated degradation of the extracellular matrix, and its possible association with MMPs, might contribute to progression of phyllodes tumors
WIN-dependent increase in the level of SPARC plays a critical role in sensitizing osteosarcoma cells to TRAIL action
high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan-Meier analysis and the log-rank test
We identified five new biomarkers: GDF15 (show GDF15 ELISA Kits), osteonectin, TRAP5, TWEAK (show TNFSF12 ELISA Kits), and YKL40 (show CHI3L1 ELISA Kits) as being promising markers for monitoring bone metastases.
CD90 (show THY1 ELISA Kits) is upregulated in gastric cancer and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.
SPARC might be an unfavorable indicator in patients with pancreatic cancer, especially in the stroma.[Review]
tracheal aspirate SPARC levels predicted development of bronchopulmonary dysplasia or death.
findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition
This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (show VEGFA ELISA Kits)), fibroblast growth factor 2 (FGF2 (show FGF2 ELISA Kits)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.
data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.
, basement-membrane protein 40
, secreted protein acidic and rich in cysteine
, cysteine-rich protein
, Secreted acidic cystein-rich glycoprotein (osteonectin)
, secreted acidic cysteine rich glycoprotein