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Human Thrombospondin 1 ELISA Kit for Sandwich ELISA - ABIN414489
Hoetzenecker, Assinger, Lichtenauer, Mildner, Schweiger, Starlinger, Jakab, Berényi, Pavo, Zimmermann, Gabriel, Plass, Gyöngyösi, Volf, Ankersmit et al.: Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and ... in Basic research in cardiology 2012
Show all 4 Pubmed References
Rat (Rattus) Thrombospondin 1 ELISA Kit for Sandwich ELISA - ABIN416163
Garcia-Diaz, Arellano, Milagro, Moreno-Aliaga, Portillo, Martinez, Campion: Glucose and insulin modify thrombospondin 1 expression and secretion in primary adipocytes from diet-induced obese rats. in Journal of physiology and biochemistry 2011
Mouse (Murine) Thrombospondin 1 ELISA Kit for Sandwich ELISA - ABIN367912
Bourgeaux, Aufradet, Campion, De Souza, Horand, Bessaad, Chevrier, Canet-Soulas, Godfrin, Martin: Efficacy of homologous inositol hexaphosphate-loaded red blood cells in sickle transgenic mice. in British journal of haematology 2012
Mouse (Murine) Thrombospondin 1 ELISA Kit for Sandwich ELISA - ABIN415440
Kang, Lim, Lee, Yeo, Kang: Anthocyanin-rich purple corn extract inhibit diabetes-associated glomerular angiogenesis. in PLoS ONE 2013
These findings shed light on the mechanisms leading to beta-cell failure during metabolic stress and point to THBS1 as an interesting therapeutic target to prevent oxidative stress in type 2 diabetes.
Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.
High plasma levels of TSP-1 are associated with increased pulmonary arterial pressure, increased pulmonary vascular resistance and decreased survival pulmonary hypertension.
Our data suggest that the molecular network including TSP-1, TGF-beta1 (show TGFB1 ELISA Kits), and PGE2 might be involved in the pathogenesis of acute angle closure glaucoma.
Genetic variants of THBS1 were significantly more frequent in patients affected by idiopathic/genetic generalized epilepsies than in non-epileptic controls.
In pulmonary hypertension TSP1-CD47 (show CD47 ELISA Kits) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
High THBS1 expression is associated with primary effusion lymphoma.
Results show that the presence of OPN (show SPP1 ELISA Kits) and TSP-1 in the serum of patients with non-small cell lung cancer may reflect the aggressiveness of the tumor.
KLK4 (show KLK4 ELISA Kits) further liberated an N-terminal product, with purported angiogenic activity, from thrombospondin-1 (TSP1) and cleaved TSP1 in an osteoblast-derived matrix.
Data suggest pituitary cells secrete factor (TSP1) that binds to and inhibits action of BMP2 and BMP4; von Willebrand type C domain of TSP1 is likely responsible for this BMP2/4-binding activity. These studies were initially conducted using cultured cells from ovine pituitary gland and mouse cell line; interactions were confirmed using recombinant human proteins. (TSP1 = thrombospondin-1; BMP = bone morphogenetic protein)
In a laser injury-induced thrombosis model, P-selectin (show SELP ELISA Kits) modulates thrombus propagation independently of VWF (show VWF ELISA Kits) and TSP1 (show GZMA ELISA Kits)
cultured astrocytes isolated from an Fmr1 (show FMR1 ELISA Kits) knockout (Fmr1 (show FMR1 ELISA Kits) KO) mouse model of Fragile X (show FMR1 ELISA Kits) syndrome displayed a significant decrease in TSP-1 (show GZMA ELISA Kits) protein expression compared to the wildtype (WT) astrocytes.
In pulmonary hypertension TSP1 (show GZMA ELISA Kits)-CD47 (show CD47 ELISA Kits) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
HIF-1alpha (show HIF1A ELISA Kits) induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (show MLXIP ELISA Kits)-21 via inhibiting a novel target gene TSP-1 (show GZMA ELISA Kits). Both of them may contribute to the protective effect of HIF-1alpha (show HIF1A ELISA Kits) on renal I/R injury.
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (show GZMA ELISA Kits)/CD47 (show CD47 ELISA Kits) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
TSP-1 (show GZMA ELISA Kits) deficiency promotes maladaptive remodelling of the ECM (show MMRN1 ELISA Kits) leading to accelerated abdominal aortic aneurysms progression.
TSP-1 (show GZMA ELISA Kits) suppressed insulin (show INS ELISA Kits) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (show MAPK8 ELISA Kits), p38 (show CRK ELISA Kits), and IKK (show CHUK ELISA Kits).
Three transcription factors were overexpressed and eleven underexpressed in TSP1 (show GZMA ELISA Kits)(-/-) compared to WT LGs (show LGSN ELISA Kits).
Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.
Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (show THBS2 ELISA Kits) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (show THBS2 ELISA Kits), up-regulates expression of FGF2 (fibroblast growth factor 2 (show FGF2 ELISA Kits)).
Thrombospondin has a role in inducing RhoA (show RHOA ELISA Kits) inactivation through FAK (show PTK2 ELISA Kits)-dependent signaling to stimulate focal adhesion disassembly
Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (show INS ELISA Kits)-like growth factor
The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications
The novel finding that TSP-1-induced migration is dependent on the CD44 (show CD44 ELISA Kits) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (show KDM5D ELISA Kits)).
These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (show IGF1 ELISA Kits) and the mechanisms by which hyperglycemia regulates TSP-1 protein.
Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (show TGFB1 ELISA Kits) expression.
ELL (show ELL ELISA Kits) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
, thrombospondin 1