Browse our BNIP3 Proteins (BNIP3)

Full name:
BCL2/adenovirus E1B 19kDa Interacting Protein 3 Proteins (BNIP3)
On www.antibodies-online.com are 5 BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Proteins from 3 different suppliers available. Additionally we are shipping BNIP3 Antibodies (166) and BNIP3 Kits (12) and many more products for this protein. A total of 192 BNIP3 products are currently listed.
Synonyms:
Nip3
list all proteins Gene Name GeneID UniProt
BNIP3 664 Q12983
BNIP3 12176 O55003
BNIP3 84480  

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More Proteins for BNIP3 Interaction Partners

Human BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) interaction partners

  1. the results suggest that BNIP3 plays a vital role in regulating PINK1 (show PINK1 Proteins) mitochondrial outer membrane localization, the proteolytic process of PINK1 (show PINK1 Proteins) and PINK1 (show PINK1 Proteins)/parkin (show PARK2 Proteins)-mediated mitophagy under physiological conditions.

  2. High BNIP3 expression is associated with chronic myelogenous leukemia.

  3. Results suggest that changes in mitochondrial morphology and transmembrane potential, induced by mutant htt (show HTT Proteins) protein, are dependent and linked to BNip3 and not to Bax (show BAX Proteins)/Bak (show BAK1 Proteins) activation.

  4. Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1alpha (show HIF1A Proteins)/BNIP3 signaling pathway.

  5. The data indicated that BNIP3 plays a vital role in the tumorigenesis of adenoid cystic carcinoma and could be a new target for gene therapy of adenoid cystic carcinoma.

  6. BNIP3 deletion can be used as a prognostic (show HIF1A Proteins)marker of tumor progression to metastasis in human triple-negative breast cancer

  7. BNIP3 expression was found to be regulated by Sp3 in prostate cancer.

  8. phosphorylation of these C-terminal BNIP3 residues blocks cell death without preventing autophagy, providing evidence that the two functional roles of BNIP3 can be regulated independently

  9. Bnip3 dual-functionality and crosstalk between mitophagy and apoptosis pathways is presented here.

  10. these findings revealed that silibinin induced autophagic cell death through ROS (show ROS1 Proteins)-dependent mitochondrial dysfunction and ATP depletion involving BNIP3 in MCF7 cells.

Mouse (Murine) BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) interaction partners

  1. In a neuronal model of dominant optic atrophy, BNIP3 down-regulation reduced autophagy and mitophagy.

  2. Down-regulation of Bcl2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3) by olomoucine, a cyclin (show PCNA Proteins)-dependent kinasesinhibitor, reduces lipopolysaccharide - and nitric oxide-induced cell death in BV2 microglial cells. Olomoucine may protect cells by limiting proinflammatory responses, thereby reducing nitric oxide generation.

  3. data outline Bnip3 as a key effector of PPARgamma (show PPARG Proteins)-mediated adipose mitochondrial network fragmentation, improving insulin (show INS Proteins) sensitivity and limiting oxidative stress.

  4. the results suggest that BNIP3 plays a vital role in regulating PINK1 (show PINK1 Proteins) mitochondrial outer membrane localization, the proteolytic process of PINK1 (show PINK1 Proteins) and PINK1 (show PINK1 Proteins)/parkin (show PARK2 Proteins)-mediated mitophagy under physiological conditions.

  5. BNIP3 interacts with the mitochondrial outer membrane directly via mitochondrial BAX (show BAX Proteins).

  6. Data show that TGFbeta (show TGFB1 Proteins)-activated kinase-1 (TAK1 (show NR2C2 Proteins)) activated nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins))/NF-kappa B (NFkappaB (show NFKB1 Proteins)), downregulated BCL2-adenovirus E1B interacting protein 3 (Bnip3), and inhibited cardiac cell death.

  7. propose that BNIP3 acts as a brake on HIF-1 (show HIF1A Proteins) activity serving to increase rates of mitophagy in response to hypoxia and to limit production of damaging ROS (show ROS1 Proteins) that would further amplify HIF-1 (show HIF1A Proteins) expression and promote tumor progression to metastasis

  8. Results suggest that Bnip3 regulates cardiac gene expression and perhaps myocyte morphology by activating nuclear p300 acetyltransferase and hyperacetylating histones and its selective transcription factors.

  9. Bnip3 dual-functionality and crosstalk between mitophagy and apoptosis pathways is presented here.

  10. regulates mitophagy during hypoxia, whereas NIX (show BNIP3L Proteins) is required for mitophagy during development of the erythroid lineage.

BNIP3 Protein Profile

Protein Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.

Alternative names and synonyms associated with BNIP3

  • BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3)
  • BCL2/adenovirus E1B interacting protein 3 (Bnip3)
  • Nip3 protein

Protein level used designations for BNIP3

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 , BCL2/adenovirus E1B 19kD-interacting protein 3 , BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3 , BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3 , BCL2/adenovirus E1B interacting protein 1, NIP3 , BCL2/adenovirus E1B 19 kDa-interacting protein 3

GENE ID SPECIES
664 Homo sapiens
423971 Gallus gallus
607408 Canis lupus familiaris
615342 Bos taurus
12176 Mus musculus
84480 Rattus norvegicus
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