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Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor (show ADRA1A Proteins) Gpr161 from the primary cilium.
G-protein-coupled receptor (show ADRA1A Proteins) GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.
False positive non-synonymous polymorphisms of G-protein coupled receptor (show ADRA1A Proteins) genes.
Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor (show GPR34 Proteins) Gpr161 from the primary cilium.
Gpr161 is a G-protein coupled receptor (show GPR34 Proteins) that regulates the retinoic acid and canonical Wnt (show WNT2 Proteins) pathways during neurulation
Complete loss of Gpr161 in mouse causes midgestation lethality and increased Shh (show SHH Proteins) signaling in the neural tube, phenocopying Tulp3 (show TULP3 Proteins)/IFT-A mutants.
Characterization of the vl mutation indicates that C-terminal tail of Gpr161 is truncated, leading to multiple effects on the protein, including reduced receptor-mediated endocytosis
Gpr161 is required for left-right patterning.
Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008
G protein-coupled receptor 161
, G-protein coupled receptor 161
, G-protein coupled receptor 161-like
, G-protein coupled receptor RE2