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These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population
Decrease in histamine H3 receptor function was linked to epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant mesial temporal lobe epilepsy.
Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R and hH4R (show HRH4 Proteins), were studied.
The polymorphisms of HNMT (show HNMT Proteins) and HRH3 were irrelevant with breast cancer in the present study.
mRNA expression of HRH-3 localized in large pigmented neurons is significantly decreased in the substantia nigra of Parkinson's patients.
ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R.
Significant association of HRH3 with antipsychotic efficacy was detected.
Histamine H3 receptor levels are unchanged in subcortical ischemic vascular dementia and mixed dementias in all brain areas studied.
The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling.
This review outlines the relevance of the histaminergic system in controlling feeding behavior and evaluates the potential role of the histamine H3 receptor as a target for regulating obesity.
H3R activation with the agonist R-(-)-alpha-methylhistamine to produce a unique time- and cell type-dependent profile of molecular signaling events in the striatum.
H3R is an important regulator of sensorimotor gating, and the lack of H3R significantly modifies striatal dopaminergic
Data show that knockout of histamine receptor H3 (Hrh3 receptor) caused a substantial reduction of free-running activity rhythm amplitude.
Histamine H3 receptors were expressed in mouse beta cells and could play a role in insulin (show INS Proteins) secretion and, possibly, beta cell proliferation.
Hrh3 polymorphisms between EAE-susceptible and resistant SJL and B10.S mice
Evidence for the role of histamine H3 receptor was found in alcohol-related behaviors, especially in alcohol drinking and alcohol reward.
An increased expression of H3 receptors in HDC (show HDC Proteins) KO mice without any changes in the spontaneous firing of "histaminergic" neurons without histamine and their responses to the H3 receptor agonist (R)-alpha-methylhistamine.
These findings demonstrate that manipulation of central histamine H3 receptor by proxyfan can significantly improve glucose excursion by increasing plasma insulin (show INS Proteins) levels via a glucose-independent mechanism.
In this review conditioned place preference induced by alcohol is stronger in histidine decarboxylase (show HDC Proteins)-deficient mice than in control mice.
Histamine H4 receptors could not be identified in five experimental models of the guinea-pig that are suited for the detection of presynaptic inhibitory receptors (hippocampus aorta, atrium, renal cortex and vas (show AVP Proteins) deferens) whereas H3 receptors could be shown in the peripheral tissues but not in the hippocampus
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.
G protein-coupled receptor 97
, G-protein coupled receptor 97
, histamine H3 receptor
, histamine H3 receptor H3L isoform
, histamine receptor H 3
, G protein-coupled receptor