Browse our anti-Glucagon Receptor (GCGR) Antibodies

Full name:
anti-Glucagon Receptor Antibodies (GCGR)
On www.antibodies-online.com are 102 Glucagon Receptor (GCGR) Antibodies from 16 different suppliers available. Additionally we are shipping Glucagon Receptor Proteins (4) and Glucagon Receptor Kits (1) and many more products for this protein. A total of 113 Glucagon Receptor products are currently listed.
Synonyms:
GCGR, GGR, GR

Most Popular Reactivities for anti-Glucagon Receptor (GCGR) Antibodies

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anti-Human Glucagon Receptor Antibodies:

anti-Mouse (Murine) Glucagon Receptor Antibodies:

anti-Rat (Rattus) Glucagon Receptor Antibodies:

All available anti-Glucagon Receptor Antibodies

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Top referenced anti-Glucagon Receptor Antibodies

  1. Human Polyclonal Glucagon Receptor Primary Antibody for IHC (p) - ABIN271047 : Mighiu, Yue, Filippi, Abraham, Chari, Lam, Yang, Christian, Charron, Lam: Hypothalamic glucagon signaling inhibits hepatic glucose production. in Nature medicine 2013 (PubMed)
    Show all 2 references for 271047

  2. Human Polyclonal Glucagon Receptor Primary Antibody for ICC, IF - ABIN4314511 : Lenders, Pacak, Huynh, Sharabi, Mannelli, Bratslavsky, Goldstein, Bornstein, Eisenhofer: Low sensitivity of glucagon provocative testing for diagnosis of pheochromocytoma. in The Journal of clinical endocrinology and metabolism 2010 (PubMed)

  3. Human Polyclonal Glucagon Receptor Primary Antibody for ELISA - ABIN314296 : Sørensen, Winzell, Brand, Fosgerau, Gelling, Nishimura, Ahren: Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function. in Diabetes 2006 (PubMed)

  4. Human Polyclonal Glucagon Receptor Primary Antibody for IF (p), IHC (p) - ABIN751528 : Rafacho, Gonçalves-Neto, Santos-Silva, Alonso-Magdalena, Merino, Taboga, Carneiro, Boschero, Nadal, Quesada: Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats. in PLoS ONE 2014 (PubMed)

More Antibodies against Glucagon Receptor Interaction Partners

Human Glucagon Receptor (GCGR) interaction partners

  1. Data suggest that GCGR activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.

  2. The activation of the GCGR is characterized by the outward movement of the intracellular side of helix VI. In the active state of the GCGR, the Arg173(2.46)-Ser350(6.41) and Glu245(3.50)-Thr351(6.42) hydrogen bonds break, and the chi1 rotamer of Phe322(5.54) changes from perpendicular to parallel to helix VI.

  3. In the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R (show GLP1R Antibodies)), the extracellular domain is required for signaling even when the hormone is covalently linked to the transmembrane domain.

  4. 2.5 A crystal structure of human GCGR in complex with the antagonist MK-0893, which is found to bind to an allosteric site outside the seven transmembrane helical bundle in a position between TM6 and TM7 extending into the lipid bilayer

  5. Molecular dynamics and disulfide crosslinking studies suggest that apo (show C9orf3 Antibodies)-GCGR can adopt both an open and closed conformation associated with extensive contacts between the ECD (show SHFM1 Antibodies) and 7TM domain. Glucagon (show GCG Antibodies) binds to GCGR by a conformational selection mechanism.

  6. glucagon (show GCG Antibodies) cell adenomatosis with GCGR germline mutations seems to follow an autosomal-recessive trait.

  7. Using a real-time time-resolved FRET-based internalization assay, we show that GLP-1R (show GLP1R Antibodies), GIPR (show GIPR Antibodies), and GCGR internalize with differential properties

  8. crystal structure of the seven transmembrane helical domain of human GCGR at 3.4 A resolution, and a hybrid model of glucagon (show GCG Antibodies) bound to GCGR to understand the molecular recognition of the receptor for its native ligand

  9. Letter/Case Report: nonfunctional glucagon (show GCG Antibodies) cell adenomatosis with no detectable glucagon receptor mutations.

  10. GRA1 is a potent glucagon receptor antagonist with strong antihyperglycemic efficacy in preclinical models and prominent effects on hepatic gene-expression related to amino acid metabolism

Mouse (Murine) Glucagon Receptor (GCGR) interaction partners

  1. GcgR knockout (Gcgr(-/-)) mice displayed lower blood glucose levels accompanied by elevated plasma ghrelin (show GHRL Antibodies) levels. Hyperglycemia was averted in streptozocin treated Gcgr(-/-) mice and the plasma ghrelin (show GHRL Antibodies) level was further increased.

  2. glucagon receptor antagonist improves glycemia in diet-induced obese angptl4 (show ANGPTL4 Antibodies) knockout mice without increasing glucagon (show GCG Antibodies) levels or alpha-cell proliferation, underscoring the importance of this protein.

  3. Data indicate that the exocrine pancreas in the glucagon receptor Gcgr-/- mice exhibited larger nuclear size than in WT or heterozygous controls, most obviously at old ages.

  4. Simultaneous and sufficient activation of GLP1R (show GLP1R Antibodies) is required to reduce GCCR (show NR3C1 Antibodies) mediated blood glucose elevation following administration of a GLP1R (show GLP1R Antibodies)/GCGR co-agonist.

  5. Knockdown of liver glucagon receptor in mice reduces blood glucose and increases blood LDL levels.

  6. Gcgr(-/-) mice became lethargic (show CACNB4 Antibodies) & cachexic & died early. Autopsy revealed numerous PNETs up to 15 mm in diameter in most well-preserved Gcgr(-/-) pancreata.

  7. Data suggest that GcgR activation raises hepatic expression of fibroblast growth factor 21 (FGF21 (show FGF21 Antibodies)) and increases circulating levels of FGF21 (show FGF21 Antibodies); GcgR activation induces body weight loss and stimulates lipid metabolism.

  8. These results suggest that a circulating factor generated after disruption of hepatic Gcgr signaling can increase alpha-cell proliferation independent of direct pancreatic input.

  9. GRA1 is a potent glucagon receptor antagonist with strong antihyperglycemic efficacy in preclinical models and prominent effects on hepatic gene-expression related to amino acid metabolism

  10. Data suggest that both Gcgr activity and glucagon-like peptide 1 (show GCG Antibodies)/Glp1r (show GLP1R Antibodies) signal transduction in central nervous system are involved in control of interscapular brown adipose tissue thermogenesis.

Glucagon Receptor (GCGR) Antigen Profile

Antigen Summary

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).

Alternative names and synonyms associated with Glucagon Receptor (GCGR)

  • glucagon receptor (GCGR) antibody
  • gastric inhibitory polypeptide receptor (GIPR) antibody
  • glucagon receptor (Gcgr) antibody
  • GCGR antibody
  • GGR antibody
  • GR antibody

Protein level used designations for GCGR

glucagon receptor , glucagon receptor-like , GL-R , glucagon receptor perhaps same as Niddm3

GENE ID SPECIES
714542 Macaca mulatta
468357 Pan troglodytes
100390029 Callithrix jacchus
100448994 Pongo abelii
100597318 Nomascus leucogenys
425670 Gallus gallus
2642 Homo sapiens
14527 Mus musculus
24953 Rattus norvegicus
483368 Canis lupus familiaris
515433 Bos taurus
100733098 Cavia porcellus
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