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MCH is an anabolic neuropeptide with multiple and diverse physiological functions including a key role in energy homoeostasis; evidence suggests that, in the reproductive context, MCH is a modulator rather than a primary regulator.
Cerebrospinal fluid (CSF) levels were measured in 33 patients with Alzheimer's disease (AD) and 33 healthy subjects, to investigate the role of MCH and HCRT-1 in AD.
the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala, are reported.
Melanin-concentrating hormone (MCH) neurons of human hypothalamus, as well as the MCH neurons of mouse hypothalamus, contain IL-6Ralpha (show IL6R Proteins).
PMCH mRNA expression level was increased 1.85 times (P < 0.01) in vitiligo (show MITF Proteins) uninvolved skin and 5.36 times (P < 0.01) in involved skin compared to healthy control skin.
Melanin-concentrating hormone is expressed and functional in human skin
RT-PCR analysis revealed a low expression of prepro-MCH and MCH receptor 1 (MCHR1 (show MCHR1 Proteins)) but not of MCHR2 transcript in tissular and peripheral blood immune cells
Review. Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, which centrally regulates food intake and stress. MCH-R1 (show MCHR1 Proteins) antagonists can probe additional functions of the peptide, both in the brain and in the peripheral nervous system.
Single nucleotide polymorphisms in pro-melanin-concentrating hormone may be associated with obesity and a greater body mass index in olanzapine-treated schizophrenic patients
expression of PMCH by activated Th2 cells in vivo may directly link allergic inflammation to energy homeostasis and may contribute to the association between asthma and obesity
Results indicate that olanzapine reduced accumbens nucleus GABAergic transmission and that MCH is necessary for the hypolocomotor effects of olanzapine
The present work is the first study to systematically compare the effects of MCH signaling on behavioral and metabolic phenotypes.[meta-analysis]
A functional cross-talk between MCH and IL-10 (show IL10 Proteins) prevents resolution of inflammation in experimental colitis.
acute activation of MCH neurons is sufficient, but not necessary, to trigger the transition from NREM to REM (show REM1 Proteins) sleep and MCH neurons also play a role in the initiation and maintenance of NREM sleep.
Sleep induction at a circadian time when all of the arousal neurons are active indicates that MCH stimulation can powerfully counteract the combined wake-promoting signal of the arousal neurons
Rat prepro-MCH is processed into three neuropeptides: melanin-concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and Neuropeptide-glycine-glutamic acid (NGE).
We conclude that MCH neurons regulate glucose tolerance through signaling molecules other than MCH.
MCH was found to promote intestinal tumorigenesis at least in part by inhibiting epithelial cell apoptosis
AgRP (show AGRP Proteins)-expressing neurons play a critical role in mediating the metabolic syndrome and infertility of Lep (show LEP Proteins)(ob/ob) mice, whereas MCH-expressing neurons have only a minor role
The hypothalamic inputs through MCH play an important role in regulating sensory integration from olfactory pathways.
The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary by Nahon et al., 1992
, pro-melanin concentrating hormone
, neuropeptide-glutamic acid-isoleucine (NEI)
, neuropeptide-glycine-glutamic acid (NGE)
, P518 precursor protein
, orexigenic neuropeptide QRFP