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Browse our ACTN3 Proteins (ACTN3)

Full name:
Actinin, alpha 3 Proteins (ACTN3)
On www.antibodies-online.com are 3 Actinin, alpha 3 (ACTN3) Proteins from 2 different suppliers available. Additionally we are shipping ACTN3 Antibodies (53) and ACTN3 Kits (27) and many more products for this protein. A total of 87 ACTN3 products are currently listed.
Synonyms:
acta-3, CG8953, dabp, Dmel\\CG8953, ORF1
list all proteins Gene Name GeneID UniProt
ACTN3 11474 O88990
Rat ACTN3 ACTN3 171009  
ACTN3 89 Q08043

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ACTN3 Proteins (ACTN3) by Origin

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Horse (Equine) Actinin, alpha 3 (ACTN3) interaction partners

  1. The ACTN3 gene is 13.2 kb long and contains 21 exons. The equine ACTN3 gene has a ubiquitous expression but it is overexpressed in skeletal muscles

Mouse (Murine) Actinin, alpha 3 (ACTN3) interaction partners

  1. Actn3 controls sarcomeric composition and muscle function in a dose-dependent fashion.

  2. New insights that have been made in understanding the molecular mechanisms that underlie the consequences of alpha-actinin-3 deficiency.[review]

  3. Absence of alpha-actinin-3 resulted in reduced atrophic response and altered adaptation to disuse, as measured by a change in myosin heavy chain isoform.

  4. ACTN3 likely contributes to the regulation of bone mass through alterations in bone turnover.

  5. Data demonstrated that the Z-disk proteins, ZASP (show LDB3 Proteins), titin (show TTN Proteins) and vinculin (show VCL Proteins) preferentially bind to alpha-actinin-2 (show ACTN2 Proteins). Thus, the loss of alpha-actinin-3 changes the overall protein composition of fast fiber Z-disks and alters their elastic properties.

  6. Actn3 knockout mice showed differences in intrinsic exercise performance, fast muscle force generation and male muscle mass.

  7. alpha-actinin-3 may play a role in the development of fast-twitch, glycolytic properties in a muscle fiber, and in its absence slower twitch, more oxidative properties may develop.

  8. alpha-Actinin-3 deficiency reduces the activity of glycogen (show GYS1 Proteins) phosphorylase and results in a fundamental shift toward more oxidative pathways of energy utilization--REVIEW

  9. alpha-actinin-3 expression in a knockout mouse model results in a shift in muscle metabolism toward the more efficient aerobic pathway and an increase in intrinsic endurance performance

  10. Study reports that muscle from Actn3 knockout mice displays reduced force generation, consistent with results from human association studies.

Human Actinin, alpha 3 (ACTN3) interaction partners

  1. These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.

  2. The elite soccer players showed a tendency to a prevalence of ACTN3 RR and ACE (show ACE Proteins) DD genotypes both independently and in co-occurrence, in comparison with a general population.

  3. the ACTN3 R577X polymorphism influences the level of competition and lower-extremity power of elite Chinese sprint/power athletes

  4. It appears that the response of bone remodelling markers and undercarboxylated osteocalcin (show BGLAP Proteins) to exercise is not explained by the ACTN3 genotype

  5. We did not identify novel associations between physical activity and ACTN3.

  6. In comparison to RR homozygotes, X allele carriers for the R577X polymorphism of the ACTN3 gene presented higher values for typical markers of exercise-induced muscle damage during a competitive marathon.

  7. There was no statistically significant association between angiotensin-converting enzyme (show ACE Proteins) or alpha-actinin-3 polymorphisms and the presence of adolescent idiopathic scoliosis in females.

  8. Study suggests that ACTN3 R577X polymorphism is associated with non-acute ankle sprain in the Chinese Han population.

  9. X-allele triathletes in the ACTN3 R577X polymorphism presented greater signs of exercise-induced muscle damage during a half-ironman race than RR homozygotes.

  10. Studied the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. 003). A significant linear correlation was found between the RR + RX genotype and athlete status.

Rabbit Actinin, alpha 3 (ACTN3) interaction partners

  1. examine the dynamics of actin in the presence of alpha-acinin in solution; suggest mechanisms to deny binding access to other actin-binding proteins and may explain how very different actin cytoskeletal structures may co-exist in the same cell

  2. Alpha-actinin may contribute to tension sensing in actin bundles.

ACTN3 Protein Profile

Protein Summary

This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is associated with elite athlete status.

Alternative names and synonyms associated with ACTN3

  • alpha actinin 3 (Actn3)
  • actinin, alpha 3 (actn3)
  • actinin, alpha 3 (ACTN3)
  • actinin alpha 3 (Actn3)
  • actinin, alpha 3 (Actn3)
  • acta-3 protein
  • CG8953 protein
  • dabp protein
  • Dmel\\CG8953 protein
  • ORF1 protein

Protein level used designations for Actinin, alpha 3 Proteins (ACTN3)

Actn3-PA , CG8953-PA , alpha-actinin-like , alpha-actinin3 , open reading frame 1 , actinin, alpha 3 , alpha-actinin-3 , alpha 3 actinin , alpha-actinin-3-like , F-actin cross-linking protein , alpha-actinin skeletal muscle , muscle alpha-actinin subunit

GENE ID SPECIES
44964 Drosophila melanogaster
446326 Xenopus laevis
713811 Macaca mulatta
100033871 Equus caballus
100216053 Xenopus (Silurana) tropicalis
100439754 Pongo abelii
11474 Mus musculus
171009 Rattus norvegicus
89 Homo sapiens
100009544 Oryctolagus cuniculus
100730348 Cavia porcellus
539375 Bos taurus
483707 Canis lupus familiaris
101115917 Ovis aries
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