Browse our anti-FLCN (FLCN) Antibodies

Full name:
anti-Folliculin Antibodies (FLCN)
On www.antibodies-online.com are 88 Folliculin (FLCN) Antibodies from 18 different suppliers available. Additionally we are shipping FLCN Kits (9) and FLCN Proteins (6) and many more products for this protein. A total of 112 FLCN products are currently listed.
Synonyms:
AU014660, B430214A04Rik, BHD, FLCL, flcn, wu:fe38g11, zgc:136982

Most Popular Reactivities for anti-FLCN (FLCN) Antibodies

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anti-Mouse (Murine) FLCN Antibodies:

anti-Rat (Rattus) FLCN Antibodies:

anti-Human FLCN Antibodies:

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Top referenced anti-FLCN Antibodies

  1. Human Polyclonal FLCN Primary Antibody for EIA, WB - ABIN453652 : Khoo, Giraud, Kahnoski, Chen, Motorna, Nickolov, Binet, Lambert, Friedel, Lévy, Ferlicot, Wolkenstein, Hammel, Bergerheim, Hedblad, Bradley, Teh, Nordenskjöld, Richard: Clinical and genetic studies of Birt-Hogg-Dubé syndrome. in Journal of medical genetics 2002 (PubMed)
    Show all 2 references for 453652

  2. Human Polyclonal FLCN Primary Antibody for ELISA, WB - ABIN531278 : Nahorski, Reiman, Lim, Nookala, Seabra, Lu, Fenton, Boora, Nordenskjöld, Latif, Hurst, Maher: Birt Hogg-Dubé syndrome-associated FLCN mutations disrupt protein stability. in Human mutation 2011 (PubMed)

More Antibodies against FLCN Interaction Partners

Mouse (Murine) Folliculin (FLCN) interaction partners

  1. FLCN regulates adipose tissue browning via mTOR (show FRAP1 Antibodies) and the transcription factor TFE3 (show TFE3 Antibodies)

  2. loss of FLCN results in a complete metabolic reprogramming of adipose tissues, resulting in enhanced oxidative metabolism.

  3. Tfe3 (show TFE3 Antibodies) overexpression in HSPCs impaired long-term hematopoietic reconstitution in vivo, recapitulating the Flcn KO phenotype, and supporting the notion that abnormal activation of Tfe3 (show TFE3 Antibodies) contributes to the Flcn KO phenotype. Flcn KO mice develop an acute histiocytic hyperplasia in multiple organs, suggesting a novel function for Flcn in macrophage development

  4. mTOR (show FRAP1 Antibodies) inhibitor, sirolimus, suppresses the tumor's growth, suggesting that mTOR (show FRAP1 Antibodies) inhibitors might be effective in control of FLCN-deficient RCC (show XRCC1 Antibodies).

  5. we show that glycogen (show GYS1 Antibodies) accumulates in kidneys from mice lacking FLCN and in renal tumors from a BHD patient

  6. Fnip1 (show FNIP1 Antibodies) and Fnip2 (show FNIP2 Antibodies) play critical roles in kidney tumor suppression in cooperation with Flcn

  7. Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation.

  8. The FLCN-GABARAP (show GABARAP Antibodies) association is modulated by the presence of either folliculin-interacting protein (FNIP)-1 (show FNIP1 Antibodies) or FNIP2 (show FNIP2 Antibodies) and further regulated by ULK1 (show ULK1 Antibodies).

  9. Flcn regulates apoptosis in lung epithelium via E-cadherin (show CDH1 Antibodies)-LKB1 (show STK11 Antibodies)-AMPK (show PRKAA1 Antibodies) axis.

  10. loss of FLCN constitutively activates AMPK (show PRKAA1 Antibodies), resulting in PGC-1alpha (show PPARGC1A Antibodies)-mediated mitochondrial biogenesis and increased ROS (show ROS1 Antibodies) production

Human Folliculin (FLCN) interaction partners

  1. Seventy-six of 156 FLCN mutation carriers (120 probands and 36 sibs, 48.7%) had skin papules; however, cutaneous manifestations were so subtle that only one patient voluntarily consulted dermatologists. Japanese Asian BHD families have three FLCN mutational hotspots.

  2. A nonsense mutation of FLCN was found in a spontaneous pneumothorax family. The results expand the mutational spectrum of FLCN in patients with Birt-Hogg-Dube syndrome.

  3. the study describes the FLCN mutation spectrum in Danish Birt-Hogg-Dube (BHD) syndrome patients, and contributes to a better understanding of BHD syndrome and management of BHD patients.

  4. We report Smith-Magenis syndrome who presents bilateral renal tumors. This is most likely related to haploinsufficiency of FLCN gene, located in the deleted region

  5. For patients whose clinical features are atypical, detection of germline mutation in FLCN gene would help confirm diagnosis. The 2 mutations we reported would expand the mutation spectrum of FLCN gene associated with BHD syndrome

  6. DNA sequence analyses determined that there was a two base pair deletion in exon 4 of the FLCN gene, confirming the diagnosis of BHD syndrome.

  7. We identified a hitherto unreported pathogenic FLCN frameshift deletion c.563delT (p.Phe188Serfs*35) in a family of a 46-year-old woman presented with macrohematuria due to bilateral chromophobe renal carcinomas

  8. FLCN irregulation in lung cysts of primary spontaneous pneumothorax is not associated with promoter methylation.

  9. mTOR (show FRAP1 Antibodies) inhibitor, sirolimus, suppresses the tumor's growth, suggesting that mTOR (show FRAP1 Antibodies) inhibitors might be effective in control of FLCN-deficient RCC (show XRCC1 Antibodies).

  10. we show that glycogen (show GYS1 Antibodies) accumulates in kidneys from mice lacking FLCN and in renal tumors from a BHD patient

FLCN Antigen Profile

Antigen Summary

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Alternative names and synonyms associated with FLCN

  • folliculin (FLCN) antibody
  • folliculin (flcn) antibody
  • folliculin (Flcn) antibody
  • AU014660 antibody
  • B430214A04Rik antibody
  • BHD antibody
  • FLCL antibody
  • flcn antibody
  • wu:fe38g11 antibody
  • zgc:136982 antibody

Protein level used designations for anti-Folliculin (FLCN) Antibodies

folliculin , folliculin-like , birt-Hogg-Dube syndrome protein homolog , BHD skin lesion fibrofolliculoma protein , birt-Hogg-Dube syndrome protein

GENE ID SPECIES
454472 Pan troglodytes
698082 Macaca mulatta
496819 Xenopus (Silurana) tropicalis
678628 Danio rerio
100158392 Xenopus laevis
100395467 Callithrix jacchus
100431335 Pongo abelii
100470222 Ailuropoda melanoleuca
216805 Mus musculus
303185 Rattus norvegicus
201163 Homo sapiens
416503 Gallus gallus
479529 Canis lupus familiaris
526652 Bos taurus
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