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Cow (Bovine) Polyclonal TLN1 Primary Antibody for EIA, WB - ABIN453977
Manevich, Grabovsky, Feigelson, Alon: Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. in The Journal of biological chemistry 2007
Human Monoclonal TLN1 Primary Antibody for IHC (p), ELISA - ABIN520958
Lai, Hua, Tsai, Wan, Lin, Chen, Chiu, Chan, Tsai, Jinn-Chyuan Sheu: Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis. in The Journal of pathology 2011
Chicken Monoclonal TLN1 Primary Antibody for ICC, FACS - ABIN439404
Longo, Ioannidu, Scotto dAbusco, Superti, Misiano, Zanoni, Politi, Mazzola, Iosi, Mura, Scandurra: Improving Osteoblast Response In Vitro by a Nanostructured Thin Film with Titanium Carbide and Titanium Oxides Clustered around Graphitic Carbon. in PLoS ONE 2016
CD90 (Thy1 (show THY1 Antibodies)) is a novel interactor of talin 1 in effector cells of autoimmune equine uveitis.
These findings suggested that Talin-1 protein was significantly upregulated in PCa (show FLVCR1 Antibodies) tissues compared with that of BPH (show GLI3 Antibodies) tissue and Talin-1 expression was an independent predictor for lymph node metastasis and biochemical recurrence of PCa (show FLVCR1 Antibodies).
Serum talin-1 had 97.7% sensitivity.
Both TLN-1 and TLN-2 (show TLN2 Antibodies) levels correlate with tumorigenicity in human HCC (show FAM126A Antibodies), indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma .
TLN1 significantly increases in refractory glioblastoma multiforme
Applying correlative imaging to link live cell and fixed immunofluorescence data on a single cell basis, we related per cell talin-1 levels to per cell measures quantitatively defining an array of cellular properties.
Disruption of the RIAM (show APBB1IP Antibodies)/lamellipodin (show RAPH1 Antibodies)-integrin-talin complex markedly impairs cell migration.
Our data demonstrate that high expression of Talin-1 is associated with significantly poorer OS and poorer DMFS in NPC (show NPC1 Antibodies) and depletion of Talin-1 expression inhibited NPC (show NPC1 Antibodies) cell migration and invasion. Talin-1 may serve as novel prognostic biomarker in NPC (show NPC1 Antibodies).
The activation of vinculin (show VCL Antibodies) by stretched talin induces a positive feedback that reinforces the actin-talin-vinculin (show VCL Antibodies) association.
Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb (show ITGA2B Antibodies)/GPIIIa (show ITGB3 Antibodies) complex transmembrane/C-terminal domains and talin-1 in cell membrane environment during platelet activation.
Data suggest that anionic lipids (such as phosphatidylinositol phosphates) play crucial role in localization of peripheral membrane proteins (such as TLN1, auxilin (show DNAJC6 Antibodies)-1, and PTEN (show PTEN Antibodies) [phosphatase and tensin homolog (show PTEN Antibodies)]). [review-like article]
FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.
These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin (show FN1 Antibodies) binding and adhesion.
Binding of vinculin (show VCL Antibodies) to the R1-R3 region of the talin rod is important for focal adhesion stability.
Data indicate that talin mechanics are isoform specific so that expression of either talin-1 or talin-2 (show TLN2 Antibodies) modulates extracellular rigidity sensing.
Conformational activation of talin by PREL-1 (show APBB1IP Antibodies) triggers integrin-mediated cell adhesion.
Direct methylation of talin, a key regulatory molecule in cell migration, by Ezh2 disrupted the binding of talin to F-actin and thereby promoted the turnover of adhesion structures.
reduction of talin-beta3 integrin (show ITGB3 Antibodies) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding
As talin engages F-actin, force exerted on the R2R3 helical bundles disrupts RIAM (show APBB1IP Antibodies) binding and exposes the vinculin (show VCL Antibodies) binding sites, which recruit vinculin (show VCL Antibodies) to stabilize the complex.
Talin1 has unique expression versus talin 2 (show TLN2 Antibodies) in the heart and modifies the hypertrophic response to pressure overload.
Talin1 and Rap1 are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss.
suggest that Tln1-mediated Itgbeta1b plays a crucial role in maintaining cardiac sarcomeric Z-disks and endothelial/endocardial cell integrity in zebrafish
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
, Talin 1