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Browse our HIPK2 Proteins (HIPK2)

Full name:
Homeodomain Interacting Protein Kinase 2 Proteins (HIPK2)
On www.antibodies-online.com are 6 Homeodomain Interacting Protein Kinase 2 (HIPK2) Proteins from 4 different suppliers available. Additionally we are shipping HIPK2 Antibodies (97) and HIPK2 Kits (4) and many more products for this protein. A total of 112 HIPK2 products are currently listed.
Synonyms:
1110014O20Rik, B230339E18Rik, cb1009, HIPK2, MGC146781, PKM, PRO0593, si:dkey-16j24.2, si:dkey-239k7.1, Stank, wu:fk56d12
list all proteins Gene Name GeneID UniProt
HIPK2 28996 Q9H2X6
HIPK2 15258 Q9QZR5
Rat HIPK2 HIPK2 362342  

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HIPK2 Proteins (HIPK2) by Origin

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More Proteins for HIPK2 Interaction Partners

Zebrafish Homeodomain Interacting Protein Kinase 2 (HIPK2) interaction partners

  1. Hipk2 promotes PP1c-mediated Dvl (show DVL2 Proteins) dephosphorylation via its C-terminal domain and is essential Dvl (show DVL2 Proteins) stability.

Human Homeodomain Interacting Protein Kinase 2 (HIPK2) interaction partners

  1. Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.

  2. Our findings indicate that phosphorylation-dependent restriction of SIRT1 (show SIRT1 Proteins) activity by HIPK2 shapes the p53 (show TP53 Proteins) response

  3. The findings highlight a complex regulation of CREB-binding protein (show CREBBP Proteins) activity by HIPK2, which might be relevant for the control of specific sets of target genes involved in cellular proliferation, differentiation and apoptosis.

  4. MDM4 (show MDM4 Proteins)/HIPK2/p53 (show TP53 Proteins) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  5. Results indicate that HIPK2 acts as a caretaker gene, whose inactivation increases tumorigenicity and causes chromosomal instability by cytokinesis failure.

  6. HIPK2 expression tends to be decreased along tumor progression and may be involved with the invasive potential, suggesting a possible tumor suppressor role for HIPK2.

  7. c-Abl (show ABL1 Proteins) was required for endogenous HIPK2 accumulation and phosphorylation of p53 (show TP53 Proteins) at Ser46 in response to DNA damage by gamma- and UV radiation.

  8. Lafora disease proteins laforin (show EPM2A Proteins) and malin (show NHLRC1 Proteins) negatively regulate the HIPK2-p53 (show TP53 Proteins) cell death pathway.

  9. HIPK2/HP1gamma (show CBX3 Proteins) pathway may uncover a new functional aspect of HIPK2 as a tumor suppressor.

  10. Analysis of these mutants revealed that HIPK1 (show HIPK1 Proteins), HIPK2 and HIPK3 (show HIPK3 Proteins) but not HIPK4 (show HIPK4 Proteins) are capable of autophosphorylating on other tyrosines

Mouse (Murine) Homeodomain Interacting Protein Kinase 2 (HIPK2) interaction partners

  1. Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.

  2. HIPK2 is ubiquitinated upon heat shock.

  3. Phosphorylation of KLF3 (show KLF3 Proteins) and CtBP2 (show CTBP2 Proteins) by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (show KLF3 Proteins).

  4. Homeodomain-interacting protein kinase 2, a novel autoimmune regulator (show AIRE Proteins) interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.

  5. Hipk2 has an essential role in mouse white fat development

  6. data identify Hipk2 as a novel regulator of C/EBPbeta (show CEBPB Proteins) and implicate different protein kinases in the cooperation of p300 (show NOTCH1 Proteins) with C/EBPbeta (show CEBPB Proteins) and C/EBPalpha (show CEBPA Proteins)

  7. Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.

  8. Hipk2 is a haploinsufficient tumor suppressor gene for mouse lymphoma development.

  9. HIPK2 is an important transcriptional cofactor that regulates bone morphogenetic protein signaling in the maintenance of enteric neurons and glia.

  10. HIPK2-mediated phosphorylation of PDX1 (show PDX1 Proteins) at Ser (show SIGLEC1 Proteins)-269 might be a regulatory mechanism connecting signals generated by changes in extracellular glucose concentration to downstream effectors, thereby influencing islet cell differentiation and function.

HIPK2 Protein Profile

Protein Summary

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HIPK2

  • homeodomain interacting protein kinase 2 (HIPK2)
  • serine/threonine protein kinase (HIPK2)
  • homeodomain interacting protein kinase 2 (hipk2)
  • homeodomain interacting protein kinase 2 (Hipk2)
  • 1110014O20Rik protein
  • B230339E18Rik protein
  • cb1009 protein
  • HIPK2 protein
  • MGC146781 protein
  • PKM protein
  • PRO0593 protein
  • si:dkey-16j24.2 protein
  • si:dkey-239k7.1 protein
  • Stank protein
  • wu:fk56d12 protein

Protein level used designations for HIPK2

homeodomain interacting protein kinase 2 , serine/threonine protein kinase , homeodomain-interacting protein kinase 2-like , homeodomain-interacting protein kinase 2 , homeodomain-interacting protein kinase-2 , hHIPk2 , nuclear body-associated kinase 1 , sialophorin tail-associated nuclear serine/threonine-protein kinase , Mx-interacting protein kinase PKM

GENE ID SPECIES
716152 Macaca mulatta
8343557 Schistosoma mansoni
100064748 Equus caballus
100359086 Oryctolagus cuniculus
100406246 Callithrix jacchus
100436791 Pongo abelii
100463537 Ailuropoda melanoleuca
100566230 Anolis carolinensis
100585699 Nomascus leucogenys
463772 Pan troglodytes
495265 Xenopus laevis
510158 Bos taurus
557551 Danio rerio
780207 Xenopus (Silurana) tropicalis
28996 Homo sapiens
15258 Mus musculus
362342 Rattus norvegicus
374138 Gallus gallus
482772 Canis lupus familiaris
100627515 Sus scrofa
101842840 Mesocricetus auratus
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