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Browse our SMAD4 (SMAD4) ELISA Kits

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SMAD Family Member 4 ELISA Kits (SMAD4)
On are 36 SMAD Family Member 4 (SMAD4) ELISA Kits from 11 different suppliers available. Additionally we are shipping SMAD4 Antibodies (175) and SMAD4 Proteins (23) and many more products for this protein. A total of 255 SMAD4 products are currently listed.
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha
list all ELISA KIts Gene Name GeneID UniProt
SMAD4 4089 Q13485
SMAD4 17128 P97471
SMAD4 50554 O70437

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More ELISA Kits for SMAD4 Interaction Partners

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. Treatment with brefelamide induced Smad4 expression, and knockdown of Smad4 by RNA interference partially diminished the inhibitory effect of brefelamide on OPN (show SPP1 ELISA Kits). These results indicate that brefelamide inhibited OPNmediated cell invasion through restoration of the OPN (show SPP1 ELISA Kits) repression by TGFbeta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) signaling

  2. The results of the present study suggested that Rac1 enhanced the expression of Smad3/4 in activated hepatic stellate cells; however, this increase may be suppressed by SAM-induced methylation of Rac1 promoters.

  3. Data indicate the TGF-beta (show TGFB1 ELISA Kits) pathway regulates the epithelial-to-mesenchymal transition (EMT (show ITK ELISA Kits)) of gastric cancer cells by increasing the levels of microRNA miRNA-181b to target Timp3 (show TIMP3 ELISA Kits) via the Smad2 (show SMAD2 ELISA Kits)/3/4-dependent pathway.

  4. Silencing of Smad4, but not Smad2 (show SMAD2 ELISA Kits) or Smad3 (show SMAD3 ELISA Kits), significantly inhibited the TGF-B1-induced miR (show MLXIP ELISA Kits)-574-3p upregulation in gastric tumor cells.

  5. AhR (show AHR ELISA Kits) affects the transforming growth factor-beta signaling pathway by inducing Smad4 degradation by the proteasome and suppressing tumor metastasis via epithelial to mesenchymal transition reduction in lung cancer cells.

  6. Loss of SMAD4 is associated with poor oncologic outcomes. SUVmax can predict loss of SMAD4 in resected left-sided pancreatic cancer. SUVmax may be a clinical biomarker for detecting loss of SMAD4 expression and predicting early systemic metastasis.

  7. The data showed that the effect of Activin A (show INHBA ELISA Kits) on ESCs (show NR2E3 ELISA Kits) was partially abrogated by pretreatment with an inhibitor of ALK4 (show ACVR1B ELISA Kits) (the type I receptor, ActRIB (show ACVR1B ELISA Kits)) and Smad4-siRNA. Cumulatively, these data suggest that Activin A (show INHBA ELISA Kits) promotes the secretion of estradiol from ESCs (show NR2E3 ELISA Kits) by increasing the expression of P450arom (show CYP19A1 ELISA Kits) via the ALK4 (show ACVR1B ELISA Kits)-Smad (show SMAD1 ELISA Kits) pathway. These findings indicate the ALK4 (show ACVR1B ELISA Kits)-Smad (show SMAD1 ELISA Kits) pathway may promote ectopic lesion survival and developmen

  8. in ascending aortic aneurysms and dissections, there is an increase in SMAD4, implicated in extracellular matrix production, possibly as an attempt to compensate for extracellular matrix deficiency

  9. Data indicate that high level of hydrogen peroxide up-regulates Smad4 protein expression and inhibits microRNA miR (show MLXIP ELISA Kits)-125b-5p expression.

  10. we discovered a novel mechanism mediated by Smad4 to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/CDC2 (show CDK1 ELISA Kits)/survivin (show BIRC5 ELISA Kits) cascade.

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.

  2. Smad4 deficiency led to aberrant transcriptional programs in antigen-specific CD8 (show CD8A ELISA Kits)(+) T cells. Findings demonstrated an essential role of Smad4 in the control of effector and memory CD8 (show CD8A ELISA Kits)(+) T-cell responses to infection.

  3. Data show that transforming growth factor beta (TGFbeta (show TGFB1 ELISA Kits))-induced changes in Gata2 transcription factor (show GATA2 ELISA Kits) and cyclin-dependent kinase inhibitor 1C (P57 (show CDKN1C ELISA Kits)) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 ELISA Kits) signaling via Smad4 protein.

  4. Smad4 knockdown blocks the effects of miR (show MLXIP ELISA Kits)-144-3p inhibitor. MiR (show MLXIP ELISA Kits)-144-3p negatively regulates osteogenic differentiation and proliferation of C3H10T1/2 cells by targeting Smad4.

  5. Studies establish Smad4 as a lung tumor suppressor and suggest that the defective DNA repair phenotype of Smad4-deficient tumors can be exploited by specific therapeutic strategies.

  6. Smad4-dependent TGF-beta (show TGFB1 ELISA Kits) signaling in smooth muscle cells protects against aortic aneurysm formation and dissection.

  7. the interplay between TGFalpha and TGF-beta (show TGFB1 ELISA Kits) signaling in pancreatic tumorigenesis

  8. The findings suggest that Smad4 is essential for initiating the ureteral smooth muscle cell differentiation program during ureter development.

  9. During high-fat diet, fed and fasting blood glucose levels, glucose stimulated insulin (show INS ELISA Kits) secretion, disposition index and glucose tolerance were significantly improved in beta-Smad4KO mice as compared with wild-type mice.

  10. This study showed that Smad4 in the oocyte is not required for oocyte or follicle development, ovulation, fertilization, preimplantation development (show MTA2 ELISA Kits), or implantation.

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  2. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (show BRD2 ELISA Kits).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (show FST ELISA Kits) are SMAD4 dependent.

  2. ALK5 (show TGFBR1 ELISA Kits) and Smad4 have roles in TGF-beta1 (show TGFB1 ELISA Kits)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (show TGFB1 ELISA Kits) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 Antigen Profile

Antigen Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4) Elisa Kit
  • Smad4 protein (smad4) Elisa Kit
  • mothers against decapentaplegic homolog 4 (LOC100342294) Elisa Kit
  • SMAD family member 4 (Smad4) Elisa Kit
  • SMAD family member 4, gene 1 (smad4.1) Elisa Kit
  • AW743858 Elisa Kit
  • D18Wsu70e Elisa Kit
  • dpc4 Elisa Kit
  • jip Elisa Kit
  • madh4 Elisa Kit
  • MYHRS Elisa Kit
  • smad4 Elisa Kit
  • Xsmad4 Elisa Kit
  • xsmad4a Elisa Kit
  • XSmad4alpha Elisa Kit

Protein level used designations for SMAD Family Member 4 (SMAD4) ELISA Kits

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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