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findings indicate a major role for Ppp1r3b in regulating hepatic glycogen (show GYS1 Antibodies) stores and whole-body glucose/energy homeostasis.
analysis of expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells
Among Mexicans, the PNPLA3 (show PNPLA3 Antibodies) (rs738409), LYPLAL1 (show LYPLAL1 Antibodies) (rs12137855), PPP1R3B (rs4240624), and GCKR (show GCKR Antibodies) (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults.
A novel role for PTG (show PPP1R3C Antibodies) in protecting hepatocellular carcinoma cells from metabolic stress, in part by regulating oxidative stress and autophagy.
Some, but not all, associations between variants in NCAN, lysophospholipase-like 1, GCKR, and PPP1R3B with hepatic steatosis (with and without increased ALT level) were significant within subpopulations.
Data indicate that genetic polymorphisms of the PPP1R3B gene may contribute to variations in plasma lipids and C-reactive protein (CRP (show CRP Antibodies)) levels among Chinese Han individuals.
Results suggest that in cultured human myotubes, glycogen (show GYS1 Antibodies)-targeting PP1 (show PPA1 Antibodies) (protein phosphatase 1 (show PPP1CB Antibodies)) subunit G(L) (coded for by the PPP1R3B gene) is expressed as in muscle tissue and is unresponsive to glucose or insulin (show INS Antibodies), as are G(M) and PTG (show PPP1R3C Antibodies) genes.
This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.
PP1 subunit R4
, hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
, protein phosphatase 1 regulatory subunit 3B
, protein phosphatase 1 regulatory subunit 4
, protein phosphatase 1 subunit GL
, hepatic glycogen-targeting subunit, G(L)
, protein phosphatase 1, regulatory (inhibitor) subunit 3B
, 33 kDa glycogen-binding protein
, protein phosphatase 1 (GL-subunit)