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this review discusses the role of CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma
CCR5 is highly expressed in active inflammatory bowel disease, and it has positive correlation with lymphocyte grade and negative correlation with expression of beta-arrestin2 (show ARRB2 Proteins).
this study shows that the dominant signature of resistance to HIV infection in this cohort of exposed but uninfected individuals was lower T-cell CCR5 expression
the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy.
Env (show ERVW-1 Proteins) regions that respond to CCR5 binding was located in the gp120 (show ITIH4 Proteins) alpha1 helix and in the gp41 HR1 heptad repeat and membrane-proximal external region.
A frameshift mutation in CCR5 was associated, but not significantly, with sporadic inclusion body myositis.
study revealed that while HIV-1 gp120 and Staph aureus LukED both target CCR5, they bind to different regions of the receptor, highlighting the divergence of the pathogens
Genetic variation of CCR5 gene demonstrates a possible association with hypertension, diabetes mellitus and atherosclerosis comorbidity in patient treated with hemodialysis.
Findings indicate the importance of chemokine (CC motif) ligand 5 (CCL5) genetic variability and CCL5-CCR5 (CC chemokine receptor 5) axis on the susceptibility to HCV.
The transferred nuclear Overhauser effect (TRNOE) crosspeaks in the ternary complex were assigned to the specific Tyr protons in the human C-C chemokine receptor 5 (CCR5) chemokine receptor peptide and to methyl protons, predominantly of isoleucine residues, and also of leucine and/or valine residues of HIV-1 gp120 envelope protein.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCR5 by coronary artery transmural and perivascular cells in a sequential pattern
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CCR5 expression.
CCR5 inhibition may provide a cardioprotective benefit in SIV infection by preventing cardiomyocyte CCR5 signaling.
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
CCR5 downregulation on CD4(+) T cells by TCR activation has no measurable effect on susceptibility to SAIDS.
CD4 and CD8 T cells are more vulnerable to SIV infection, indicating the the ability to express CCR5 may activate and hassten T cell death by SIV infection in vitro.
Results estimate the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut (show GUSB Proteins).
observed a significantly higher loss of CCR5(+) CD45RA(-) CD4 (show CD4 Proteins)(+) T cells in CD8 (show CD8A Proteins)(+) lymphocyte-depleted macaques than in controls
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 (show CXCR4 Proteins) for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 (show CXCR4 Proteins) almost exclusively
The Ccr5 is crucial in directing T cells toward the Langat virus -infected brain, as well as in suppressing neutrophil-mediated inflammation within the Central Nervous System.
This study showed that CCR5 ablation exacerbated Japanese encephalitis without altering viral burden in the extraneural and CNS tissues, as manifested by increased CNS infiltration of Ly-6C(hi) monocytes and Ly-6G(hi) granulocytes.
These results suggested that CCR5 signaling is involved in embryo loss in Toxoplasma gondii infection during early pregnancy and that apoptosis is associated with embryo loss rather than direct damage to the fetoplacental tissues.
The upregulation of CCR5 on the surface of the CD8 (show CD8A Proteins)(+) T cells increases the number of contacts with Ag-bearing dendritic cells, which ultimately results in increased CD8 (show CD8A Proteins)(+) T cell response to Ag rechallenge.
CCL4-CCR5 axis can contribute to breast cancer metastasis to bone by mediating the interaction between cancer cells and fibroblasts in bone cavity.
Cytokine-induced killer cells interact with tumor lysate-pulsed dendritic cells via CCR5 signaling.
this study shows that diosgenin-mediated anti-allergic effects are associated with increased number of Foxp3+ Treg cells expressing CCR5
CCR5 deficiency increased the production of TNF-alpha (show TNF Proteins) following LPS (show TLR4 Proteins) treatment through increased activation of the p38 (show CRK Proteins) pathway in the kidney, resulting in renal apoptosis and leukocyte infiltration and led to exacerbation of LPS (show TLR4 Proteins)-induced acute kidney injury.
In West Nile virus infection of the central nervous system, CCR5 activity is required to limit viral burden in the cerebral cortex.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
C-C chemokine receptor type 5
, C-C motif chemokine receptor 5 A159A
, HIV-1 fusion coreceptor
, chemokine receptor CCR5
, C-C CKR-5
, MIP-1 alpha receptor
, chemokine (C-C) receptor 5
, chemokine C-C motif receptor 5
, C-C chemokine receptor 11 like
, CC chemokine receptor 5
, chemokine receptor 5
, CC chemokine receptor type 5
, C-C chemokine receptor 5
, chemokine (C-C motif) receptor 5
, C-C chemokine receptor 5 like
, C-C chemokine receptor type 2
, C-C chemokine receptor type 5-like