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Data indicate the MHC class I-LILRB1 signaling axis as an important regulator of the effector function of innate immune cells.
RT-PCR analysis of serum samples confirmed that miR-7-5p and miR (show MLXIP Proteins)-26b-5p were upregulated in the serum of left ventricular hypertrophy hypertensive patients compared with healthy subjects. Our findings suggest that these miRNAs may play a role in the pathogenesis of hypertensive left ventricular hypertrophy and may represent novel biomarkers for this disease.
LILRB1 ligation during the differentiation of monocytes to dendritic cells in vitro results in increased ABIN1 (show TNIP1 Proteins) expression. ABIN1 (show TNIP1 Proteins) mediates the effects of LILRB1 ligation-induced inhibitory effects on immune responses.
the results support that a regulated assembly of these noncanonical HLA-I conformers during the immune response may enhance the avidity of their interaction with LILRB1.
miR7 negatively regulates PAK1 (show PAK1 Proteins) protein expression but has no effect on PAK1 (show PAK1 Proteins) mRNA expression. Knockdown of PAK1 (show PAK1 Proteins) expression markedly suppressed thyroid cancer cell proliferation, migration and invasion.
this study shows that in the tuberculosis with pleural effusion -PE cases, ILT-2 expressing cells are reduced at the local disease site
a woman's heterozygosity in HLA-G (show HLAG Proteins) and LILRB1 might be an advantage for a success of reproduction, but the partner's heterozygosity in 9A/10A KIR2DL4 (show KIR2DL4 Proteins) alleles might not
Surprisingly, the ability of LIR1(+) natural killer cells to control virus spread differed between human cytomegalovirus strains, and this phenomenon was dependent on amino acid sequences within the viral ligand UL18.
LIR-1 expression on CD8 (show CD8A Proteins)+ T cells in Rheumatoid Arthritis patients was higher than that in healthy controls.
One SNP in LILRB1 (5724G>A) influenced the risk of NSCLC. 5724G>A was associated with protection from tumor cell infiltration of regional lymph nodes. Expression in tumor tissue correlated with tumor stage.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
CD85 antigen-like family member J
, Ig-like transcript 2
, leukocyte immunoglobulin-like receptor subfamily B member 1
, leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform
, monocyte/macrophage immunoglobulin-like receptor 7