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anti-Human MLH3 Antibodies:
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Dog (Canine) Polyclonal MLH3 Primary Antibody for ELISA - ABIN249597
Lipkin, Wang, Jacoby, Banerjee-Basu, Baxevanis, Lynch, Elliott, Collins: MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. in Nature genetics 2000
these data identify Mlh1 (show MLH1 Antibodies) and Mlh3 as novel critical genetic modifiers of HTT (show HTT Antibodies) CAG instability, point to Mlh1 (show MLH1 Antibodies) genetic variation as the likely source of the instability difference in B6 and 129 strains
Mlh3 is required for Mlh1 (show MLH1 Antibodies) binding to meiotic chromosomes and localizes to chromosomes from the mid pachynema stage of prophase. Mlh3(-/-) spermatocytes reach metaphase before succumbing to apoptosis, oocytes fail to complete meiosis I after fertilization.
Associated with MSH4 (show MSH4 Antibodies) in mammalian meiotic cells, supporting the possibility that MLH3 plays a role in meiotic recombination.
Data show partial functional redundancy between MLH3 and PMS2 (show PMS2 Antibodies) orthologues for mutation avoidance and show a role for Mlh3 in gastrointestinal and extragastrointestinal tumor suppression.
Mlh3 normally inhibits the accumulation of mutations in somatic hypermutation
DNA mismatch repair Mlh3 protein plays a role in both class switch DNA recombination and somatic hypermutation
These results indicate that approximately 10% of crossovers in the mouse are independent of MLH3, suggesting the existence of alternative crossover pathways in mammals.
Mlh3 nullizygosity significantly increased Apc (show APC Antibodies) frameshift mutations and tumor multiplicity.
MLH3-independent crossovers in mammalian meiosis,in Mus81 (show MUS81 Antibodies)-nullizygous mice.
A polymorphism within the MLH3 gene is associated with oligozoospermia in Caucasian men of a certain area.
MutL homolog 3 (MLH3) promoter methylation was observed in 61% of oligoastrocytoma and 27% of astrocytoma.
the MutSbeta-MutLalpha interaction is mediated in part by residues ((L/I)SRFF) embedded within the MSH3 (show MSH3 Antibodies) PCNA (show PCNA Antibodies)-binding motif
hMLH3 mRNA is present at low levels in numerous tissues but high levels in testis. hMLH3 functions in meiosis as well as hMSH2 (show MSH2 Antibodies)-hMSH3 (show MSH3 Antibodies) repair processes & has little if any role in Hereditary Non-Polyposis Colorectal Cancer (HNPCC (show MLH1 Antibodies)).
There is an association of polymorphism C85T in MSH5 (show MSH5 Antibodies) or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 (show MSH5 Antibodies) and MLH3 polymorphisms increased the risk of developing male infertility
Little evidence for involvement of MLH3 in colorectal cancer predisposition.
at pachynema, when chromosomes are fully paired, we find significant heterogeneity in the localization of the MutL homologs, MLH1 (show MLH1 Antibodies) and MLH3, among human oocyte populations
The identification of inherited missense variants, somatic missense mutations (present in 3 of 57 tumors), and LOH in the tumor from a patient with a germ line missense change suggest a role for MLH3 in endometrial tumorigenesis.
Mutations of Mlh3 may work together with other genes in an accumulated manner and result in an increased risk of esophageal tumor
in absence of hPMS2, hMLH3 (hMutLgamma) is located in the nucleus, suggesting a conditional activity in MMR (show MRC1 Antibodies) and supporting its role as a low-risk gene in hereditary non-polyposis colorectal cancer
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
DNA mismatch repair protein Mlh3
, mutL 3
, mutL homolog 3
, mutL homolog 3 (E. coli)
, DNA mismatch repair protein Mlh3-like