|Reactivity||Baboon, Chimpanzee, Human, Monkey Alternatives|
|Conjugate||This CD59 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-CD59 AntibodyTarget Details CD59 Application Details Handling Images
|Specificity||Recognizes CD59 Glycoprotein.|
Species reactivity (expected):Baboon, Chimpanzee and Monkey.
Species reactivity (tested):Human.
|Characteristics||Synonyms: MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21,MACIF, MAC-IP, MIRL, HRF20, HRF-20, Membrane attack complex inhibition factor,Membrane inhibitor of reactive lysis, 20 kDa homologous restriction factor|
|Immunogen||Full length protein corresponding to Human CD59.|
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|Alternative Name||CD59 (CD59 Antibody Abstract)|
|Background||CD59, an LY6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin|
|Research Area||Cardiovascular, Atherosclerosis, Hematopoietic Progenitors, Tyrosine Kinases, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells|
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Flow Cytometry: 2 μg/IE6 cells. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Buffer||PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.
|Expiry Date||12 months|
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