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Using electron microscopy combined with targeted mutations, the authors show that under physiologically relevant conditions, both the Syt1 ring assembly and its rapid disruption by Ca(2+) involve the well-established functional surfaces on the C2B domain that are important for synaptic transmission.
This study found that the CSF (show CSF2 Antibodies) levels of synaptotagmin-1 (show SYT1 Antibodies) were consistently elevated in patients with dementia due to Alzheimer's disease.
Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18-SSX2 (show SSX2 Antibodies) tumors. Re-analysis of human SS18-SSX1 (show SSX1 Antibodies) and SS18-SSX2 (show SSX2 Antibodies) tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 (show SSX2 Antibodies) expression in SS18-SSX1 (show SSX1 Antibodies) tumors.
SYT-SSX (show SSX2 Antibodies) fusion is associated with synovial sarcoma.
the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (show CA2 Antibodies)+)-regulated tethers to the Pplasma membrane.
Data indicate that small protein sequence changes in the Ca(2 (show CA2 Antibodies)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 (show SYT1 Antibodies) and Syt-7 (show SYT7 Antibodies) isoforms.
Kidney transplant recipients' polymorphisms of genes associated with telomere length, BICD1 (show BICD1 Antibodies) and chromosome 18, but not hTERT, affect kidney allograft early and long-term function after transplantation.
Data show that SS18/SSX (show SSX2 Antibodies) tightly regulates the elevated expression of the key Wnt (show WNT2 Antibodies) target AXIN2 (show AXIN2 Antibodies) in primary synovial sarcoma.
These findings identify Syt1 (show SYT1 Antibodies) as a novel Ca(2 (show CA2 Antibodies)+)-sensitive PS1 (show PSEN1 Antibodies) modulator that could regulate synaptic ABETA (show APP Antibodies), opening avenues for novel and selective synapse targeting therapeutic strategies.
One-Step reverse transcriptase real time PCR for the detection SYT-SSX (show SSX2 Antibodies) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.
disruption of the Ss18 gene results in a recessive embryonic lethal phenotype, due to placental failure caused by impairment of placental vascularization and/or chorio-allantoic fusion
Syt may contribute to the signaling pathway important for various cellular functions in vivo and in vitro, and we propose that Syt-deficient MEFs would be a powerful means to understand the biological roles of SYT in vitro.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
, synovial sarcoma associated SS18-beta
, synovial sarcoma associated SS18-delta
, synovial sarcoma associated SS18-gamma
, synovial sarcoma, translocated to X chromosome
, synovial sarcoma-associated Ss18-alpha
, synovial sarcoma translocated to X chromosome protein
, synovial sarcoma translocation, chromosome 18
, synovial sarcoma translocation, chromosome 18 L homeolog