Browse our MLH1 (MLH1) ELISA Kits

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MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) ELISA Kits (MLH1)
On www.antibodies-online.com are 4 MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) ELISA Kits from 3 different suppliers available. Additionally we are shipping MLH1 Antibodies (179) and MLH1 Proteins (9) and many more products for this protein. A total of 199 MLH1 products are currently listed.
Synonyms:
1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301
list all ELISA KIts Gene Name GeneID UniProt
Mouse MLH1 MLH1 17350 Q9JK91
MLH1 4292 P40692
Rat MLH1 MLH1 81685 P97679

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More ELISA Kits for MLH1 Interaction Partners

Xenopus laevis MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Results suggest that Xenopus MBD4 (show MBD4 ELISA Kits)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.

Zebrafish MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.

  2. In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.

  3. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 ELISA Kits) genes, mlh1, msh2 (show MSH2 ELISA Kits), and msh6 (show MSH6 ELISA Kits), in zebrafish that develop tumors at low frequencies.

Mouse (Murine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  2. high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected

  3. radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.

  4. these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT (show HTT ELISA Kits) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains

  5. Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.

  6. nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  7. suggesting a role for the ATPase (show DNAH8 ELISA Kits) activity of MLH1 beyond the activation of the endonuclease functions of its MMR (show MRC1 ELISA Kits) partner PMS2 (show PMS2 ELISA Kits)

  8. Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (show ARHGEF16 ELISA Kits) and brain tumour multicellular spheroids.

  9. MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.

  10. Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (show MRC1 ELISA Kits) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.

Human MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. MLH1 mutations contribute to colorectal cancer susceptibility in Algerian families with suspected Lynch syndrome.

  2. MLH1 methylation analysis defines a subset of tumors that have worse prognostic features including higher tumor volume and lymph node involvement.

  3. High MLH1 expression is associated with the development of genetic instability and is linked to tumor aggressiveness and early PSA recurrence in prostate cancer.

  4. MLH1 methylation is a frequent molecular event in colorectal cancer and lung cancer patients

  5. Both the mTOR (show FRAP1 ELISA Kits)/p-mTOR (show FRAP1 ELISA Kits) and BNIP3 (show BNIP3 ELISA Kits)/Beclin-1 (show BECN1 ELISA Kits) signaling pathways were found to be related to HRS, but only mTOR (show FRAP1 ELISA Kits)/p-mTOR (show FRAP1 ELISA Kits) is involved in the regulation of HRS via MLH1 and autophagy.

  6. Data suggest that yeast Mlh1-Mlh3 heterodimer does not exhibit hallmarks of a canonical (structure-selective) Holliday junction resolvase/endonuclease; multiple Mlh1-Mlh3 heterodimers appear to load onto DNA to form an activated polymer that cleaves DNA; human MLH1-PMS2 (show PMS2 ELISA Kits) exhibits similar characteristics. (MLH = mutL homolog protein; PMS2 (show PMS2 ELISA Kits) = post meiotic segregation increased 2 protein)

  7. a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  8. Genetic changes between MLH1 and MSH2 (show MSH2 ELISA Kits) were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 (show MSH2 ELISA Kits) and DVL3 (show DVL3 ELISA Kits) genes (p = 0.034).

  9. Mismatch repair (MMR (show MRC1 ELISA Kits))-deficient endometrial carcinomas have significantly increased tumoral and immune stromal PD-L1 (show CD274 ELISA Kits) expression relative to MMR (show MRC1 ELISA Kits)-intact carcinomas. PD-L1 (show CD274 ELISA Kits) is frequently positive in both tumoral and immune cells at the periphery of MMR (show MRC1 ELISA Kits)-deficient tumors. Lynch syndrome-associated tumors are more likely to express PDL1 (show CD274 ELISA Kits) relative to sporadic MLH1 promoter hypermethylation carcinomas.

  10. These results demonstrate the role of variant rs1800734 in altering transcription factor binding as well as epigenetics at regions beyond the MLH1 CpG island in which it is located.

Cow (Bovine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.

MLH1 Antigen Profile

Antigen Summary

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Alternative names and synonyms associated with MLH1

  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1) Elisa Kit
  • CG11482 gene product from transcript CG11482-RB (Mlh1) Elisa Kit
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (mlh1) Elisa Kit
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1) Elisa Kit
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (LOC100232198) Elisa Kit
  • mutL homolog 1 (E. coli) (Mlh1) Elisa Kit
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Mlh1) Elisa Kit
  • 1110035C23Rik Elisa Kit
  • AI317206 Elisa Kit
  • AI325952 Elisa Kit
  • AI561766 Elisa Kit
  • CG11482 Elisa Kit
  • COCA2 Elisa Kit
  • Dmel\\CG11482 Elisa Kit
  • dmlh-1 Elisa Kit
  • dmlh1 Elisa Kit
  • FCC2 Elisa Kit
  • hMLH1 Elisa Kit
  • HNPCC Elisa Kit
  • HNPCC2 Elisa Kit
  • LOC100232198 Elisa Kit
  • MLH1 Elisa Kit
  • zgc:66301 Elisa Kit

Protein level used designations for MLH1

MutL protein homolog 1 , CG11482-PA , CG11482-PB , Mlh1-PA , Mlh1-PB , DNA mismatch repair protein Mlh1 , mutL-like protein 1 , mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) , DNA mismatch repair protein Mlh1-like , colon cancer, nonpolyposis type 2 , mutL protein homolog 1 , mismatch repair protein 1

GENE ID SPECIES
420729 Gallus gallus
35796 Drosophila melanogaster
100036779 Xenopus laevis
100337665 Sus scrofa
393632 Danio rerio
588545 Strongylocentrotus purpuratus
747104 Pan troglodytes
100011682 Monodelphis domestica
100050351 Equus caballus
100232198 Taeniopygia guttata
100406787 Callithrix jacchus
100436876 Pongo abelii
100476536 Ailuropoda melanoleuca
100555611 Anolis carolinensis
100593390 Nomascus leucogenys
17350 Mus musculus
4292 Homo sapiens
81685 Rattus norvegicus
477019 Canis lupus familiaris
533652 Bos taurus
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