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The C-terminal domains of the Sld5 and Psf1 (show TAP1 Antibodies) subunits are connected by linker regions to the core complex, and the C-terminal domain of Sld5 is important for core complex assembly.
Attenuation of SLD5 expression results in marked DNA damage in both normal cells and cancer cells, suggesting that it protects against DNA damage.
Requirement of SLD5 for early embryogenesis.
These data suggest that PSF1 (show TAP1 Antibodies) and SLD5 may cooperate in the proliferation of immature cell populations.
The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1\; MIM 610608), Psf2 (GINS2\; MIM 610609), and Psf3 (GINS3\; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005
DNA replication complex GINS protein SLD5
, SLD5 homolog