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Human Polyclonal PSME4 Primary Antibody for ICC, IF - ABIN4348310
Welk, Coux, Kleene, Abeza, Trümbach, Eickelberg, Meiners: Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes. in The Journal of biological chemistry 2016
identified a novel 200 kDa nuclear protein (show RDBP Antibodies) that activates the proteasome; findings implicate PA200 in DNA repair, possibly by recruiting proteasomes to double strand breaks
Study demonstrated that Psme3 (show PSME3 Antibodies)/Psme4 double KO (dKO) male mice are completely infertile and showed the up-regulation of several proteins involved in oxidative stress response in dKO sperms. These results suggest the important role of PA28gamma (show PSME3 Antibodies) and PA200 in male fertility.
PA200/Blm10 specifically targets the core histones for acetylation-mediated degradation by proteasomes, providing mechanisms by which acetylation regulates histone degradation, DNA repair, and spermatogenesis.
Activates proteasomal cleavage of peptides in an energy- independent manner. May be involved in spermatogenesis. May be involved in DNA repair.
proteasome (prosome, macropain) activator subunit 4
, proteasome activator PA200
, proteasome activator complex subunit 4
, proteasome activator subunit 4
, proteasome activator 200 kDa