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AP2 (show GTF3A ELISA Kits) has evolved as a key regulatory node to coordinate clarhtin-coated pit (show IRF6 ELISA Kits) formation and cargo sorting and ensure high spatial and temporal regulation of cathrin-mediated endocytosis.
BMCC1 (show PRUNE2 ELISA Kits) is an AP-2 (show GTF3A ELISA Kits) associated endosomal protein in prostate cancer cells.
We identify dynamin and the EAP-binding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in clathrin mediated endocytosis.
a conserved heretofore unrecognized YXXPhi motif (Phi is a bulky hydrophobic residue) within the core protein. This motif is homologous to sorting signals within host cargo proteins known to mediate binding of AP2M1
Arkadia (show RNF111 ELISA Kits) complexes with clathrin adaptor AP2 (show GTF3A ELISA Kits) mu2 subunit and regulates EGF (show EGF ELISA Kits) signalling.
These results suggest that AP-2 (show GTF3A ELISA Kits) is essential for endocytic clathrin coated-pit (show IRF6 ELISA Kits) and coated-vesicle formation.
multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis.
V1H can function as an adaptor for interactions between Nef and AP-2 (show GTF3A ELISA Kits).
direct association of the adaptor complex 2 with a G protein-coupled receptor has not been reported so far and might represent a common mechanism underlying clathrin-mediated receptor endocytosis
Results indicate that AP-2 is not essential for clathrin-coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins.
Binding of AP-2 (show TFAP2A ELISA Kits) to otoferlin (show OTOF ELISA Kits) facilitates replenishment of release sites, for example, via speeding AZ clearance of exocytosed material, in addition to a role of AP-2 (show TFAP2A ELISA Kits) in synaptic vesicle reformation.
Data shsow that mutation of residues at the DEP (show ZDHHC21 ELISA Kits)-mu2 contact or in the tyrosine motif reduce affinity of Dvl2 (show DVL2 ELISA Kits) for mu2.
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.
AP-2 complex subunit mu-1-A
, AP-2 complex subunit mu-A
, AP-2 mu-2 chain A
, AP-2 mu-A chain
, adaptor protein complex AP-2, mu1
, clathrin assembly protein complex 2 medium chain A
, clathrin coat assembly protein AP50-A
, clathrin coat-associated protein AP50-A
, plasma membrane adaptor AP-2 50 kDa protein A
, AP-2 complex subunit mu-1-B
, AP-2 complex subunit mu-B
, AP-2 mu-2 chain B
, AP-2 mu-B chain
, clathrin assembly protein complex 2 medium chain B
, clathrin coat assembly protein AP50-B
, clathrin coat-associated protein AP50-B
, plasma membrane adaptor AP-2 50 kDa protein B
, AP-2 complex subunit mu
, AP-2 complex subunit mu-1
, AP-2 mu chain
, AP-2 mu-2 chain
, clathrin assembly protein complex 2 medium chain
, clathrin coat assembly protein AP50
, clathrin coat-associated protein AP50
, plasma membrane adaptor AP-2 50 kDa protein
, adaptor-related protein complex 2, mu 1 subunit
, AP-2 complex subunit mu-like
, clathrin coat assembly protein ap50
, AP-2 mu 2 chain
, HA2 50 kDA subunit
, adapter-related protein complex 2 mu subunit
, adaptor protein complex AP-2 subunit mu
, clathrin adaptor complex AP2, mu subunit
, clathrin coat adaptor protein AP50
, clathrin-associated/assembly/adaptor protein, medium 1
, plasma membrane adaptor AP-2 50kDA protein
, adaptor-related protein complex AP-2, mu1
, clathrin-associated AP-2
, coat assembly protein complex 50 kD
, HA2 50 kDa subunit