Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human ARHGEF7 Antibodies:
anti-Rat (Rattus) ARHGEF7 Antibodies:
anti-Mouse (Murine) ARHGEF7 Antibodies:
Go to our pre-filtered search.
Chicken Monoclonal ARHGEF7 Primary Antibody for IF, WB - ABIN968623
Bagrodia, Taylor, Jordon, Van Aelst, Cerione: A novel regulator of p21-activated kinases. in The Journal of biological chemistry 1998
Show all 4 Pubmed References
Rat (Rattus) Monoclonal ARHGEF7 Primary Antibody for IF, WB - ABIN968624
Manser, Loo, Koh, Zhao, Chen, Tan, Tan, Leung, Lim: PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. in Molecular cell 1998
Show all 4 Pubmed References
Human Polyclonal ARHGEF7 Primary Antibody for ICC, ELISA - ABIN1169227
Oh, Yoo, Jo, Song, Kim, Park: Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. in Biochemical and biophysical research communications 1997
each mutation in LRRK2 (show LRRK2 Antibodies) and ARHGEF7 demonstrated its unique functional property, which may contribute to the pathogenesis of Parkinson disease
we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease
Data show association of G protein-coupled receptor (show ADRA1A Antibodies) kinase-interacting protein (show CIB1 Antibodies) 1 (GIT1), p21 (show CDKN1A Antibodies)-activated kinase interacting exchange factor (betaPIX), and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1 (show PAK1 Antibodies)) with centrosomes.
Data show the role of Rho guanine nucleotide exchange factor 7 (beta-PIX) to the regulation of high mobility of lung adenocarcinoma cell line H1299 via regulation of focal adhesions dynamics, changes in actin cytoskeleton organization and cell polarity.
Phosphorylation of LRRK2 (show LRRK2 Antibodies) by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7.
GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain.
Conversely, increased expression of betaPIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap (show YAP1 Antibodies)/Taz (show TAZ Antibodies), promoting localization of Yap (show YAP1 Antibodies)/Taz (show TAZ Antibodies) to the cytoplasm and inhibiting cell migration and proliferation.
Data indicate that suppression of c-Cbl (show CBL Antibodies) protein by rho guanine nucleotide exchange factor 7 (Cool-1) may be critical for generation of at least a subset of glioblastoma (GBM).
The interaction of betaPix with srGAP1 (show SRGAP1 Antibodies) is critical for maintaining suppressive crosstalk between Cdc42 (show CDC42 Antibodies) and RhoA (show RHOA Antibodies) during 3D collagen migration.
BetaPix phosphorylation at Ser (show SIGLEC1 Antibodies)-340 upregulates Nox1 (show NOX1 Antibodies) through Rac (show AKT1 Antibodies) activation.
It provides for the first time, to our knowledge, a possible mechanism for the concerted action of tyrosine kinases, GIT1/betaPIX proteins, and Ca(2 (show CA2 Antibodies)+) in the propagation of signals leading to the regulation of microtubule nucleation in activated mast cells.
beta-Pix controls the spatial localization of Rac1 activity to drive collective AVE migration at a critical stage in mouse development.
Therefore, we propose that PKCgamma (show PRKCG Antibodies) positively modulates dopamine release through beta2PIX phosphorylation.
Glucose stimulates Cav-1 (show CAV1 Antibodies) and induces its dissociation from Cdc42 (show CDC42 Antibodies), to promote Cdc42 (show CDC42 Antibodies)-betaPix binding and Cdc42 (show CDC42 Antibodies) activation, and to trigger downstream signaling and ultimately sustain insulin (show INS Antibodies) release.
a model by which SNX27 (show SNX27 Antibodies) regulates trafficking of beta-Pix to focal adhesions and thereby influences cell motility.
betaPix-b(L) induced pinocytosis through cooperative action of the CH and Dbl (show MCF2 Antibodies) homology (DH) domains, demonstrating the role of betaPix-b(L) in the regulation of membrane dynamics
Stat3 binds to betaPIX, a Rac1 activator,and regulates Rac1 activity to modulate the organization of actin cytoskeleton and directional migration
phosphorylation-dephosphorylation cycle of Cool-1 at Tyr (show TYR Antibodies)-442 can serve as a key regulatory signal for focal complex assembly-disassembly, and consequently, for the migration and invasive activity of Src (show SRC Antibodies)-transformed
P85 beta-PIX, located downstream of Rac1, is a key regulator for the activations of FAK (show PTK2 Antibodies) or p38 MAP kinase (show MAPK14 Antibodies) and plays a pivotal role in focal complex formation and cell motility.
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Rho guanine nucleotide exchange factor (GEF) 7
, Rho guanine nucleotide exchange factor 7
, rho guanine nucleotide exchange factor 7-like
, PAK-interacting exchange factor beta
, SH3 domain-containing proline-rich protein
, guanine nucleotide exchange factor 7
, rho guanine nucleotide exchange factor 7
, Pak interacting exchange factor
, Pak3 binding protein