Browse our Geminin, DNA Replication Inhibitor Proteins (GMNN)

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Geminin, DNA Replication Inhibitor Proteins (GMNN)
On are 14 Geminin, DNA Replication Inhibitor (GMNN) Proteins from 7 different suppliers available. Additionally we are shipping Geminin, DNA Replication Inhibitor Antibodies (108) and Geminin, DNA Replication Inhibitor Kits (2) and many more products for this protein. A total of 126 Geminin, DNA Replication Inhibitor products are currently listed.
anon-WO0257455.1, AW546347, CG3183, Dmel\\CG3183, Dm geminin, DyakGE24654, dyak_GLEANR_833, GB16871, GE24654, gem, geminin, GMNN, l(2)k14019, LOC100049517, sb:cb254, v(2)k09107, zgc:66217
list all proteins Gene Name GeneID UniProt
GMNN 57441 O88513
GMNN 291137  
GMNN 51053 O75496

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Geminin, DNA Replication Inhibitor Proteins (GMNN) by Origin

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Top referenced Geminin, DNA Replication Inhibitor Proteins

  1. Human GMNN Protein expressed in Escherichia coli (E. coli) - ABIN667697 : Luo, Yang, Takihara, Knoetgen, Kessel: The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. in Nature 2004 (PubMed)
    Show all 3 references for 667697

More Proteins for Geminin, DNA Replication Inhibitor Interaction Partners

Fruit Fly (Drosophila melanogaster) Geminin, DNA Replication Inhibitor (GMNN) interaction partners

  1. In the absence of geminin, limited pre-replicative complex assembly was restricted to the heterochromatin by elevated cyclin A (show CCNA2 Proteins)-CDK (show CDK4 Proteins) activity.

  2. Gem and Brm (show SMARCA2 Proteins) act antagonistically to modulate the EGFR (show EGFR Proteins)-Ras-MAPK (show MAPK1 Proteins) signaling pathway, by affecting Mek (show MAP2K1 Proteins) levels during Drosophila development

  3. In cycling cells, Dup (show CDT1 Proteins) destruction is coupled to DNA replication and that increased levels of Gem balance elevated Dup (show CDT1 Proteins) levels to prevent pre-replicative complex reformation when Dup (show CDT1 Proteins) degradation fails.

  4. Down-regulation of APC (show APC Proteins)/C activity results in stabilization of Geminin protein and blocks endocycle progression.

Zebrafish Geminin, DNA Replication Inhibitor (GMNN) interaction partners

  1. results demonstrate that geminin is required for proper Kupffer's vesicle formation and ciliogenesis, thus playing an important part in setting up left-right asymmetry.

  2. Results from a dual-luciferase assay in HEK293 cells showed that ZDND increases the translation of geminin

Mouse (Murine) Geminin, DNA Replication Inhibitor (GMNN) interaction partners

  1. These results provide proof-of-principle that preventing geminin function could prevent malignancy in tumors derived from pluripotent cells by selectively eliminating the progenitor cells with little harm to normal cells.

  2. cell penetrating (CP) Geminin is imported into the nucleus after incorporation and also the incorporated CP-Geminin directly interacted with Cdt1 (show CDT1 Proteins) or Brahma (show SMARCA2 Proteins)/Brg1 (show SMARCA4 Proteins) as the same manner as Geminin

  3. Study shows that ablation of Geminin induces massive rereplication as a result of unrestrained Cdt1 (show CDT1 Proteins) activity in embryonic stem cells, whereas it has no such effect in embryonic fibroblasts in which alternative regulation of Cdt1 (show CDT1 Proteins) activity is intact.

  4. Maternal geminin does not regulate oogenesis and oocyte meiotic maturation, but it does control accurate DNA replication and timely cleavage of fertilized eggs.

  5. Regulation of gene expression by geminin occurs only after pluripotent cells differentiate into cells in which geminin is not essential for viability.

  6. Geminin is an important regulator of self-renewal and survival of enteric nervous system progenitor cells.

  7. geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system.

  8. these data demonstrate a requirement for Geminin for neural tube patterning and neuronal differentiation during mammalian neurulation in vivo.

  9. geminin is required for Sox2 (show SOX2 Proteins) expression, and thus for the maintenance of totipotency, pluripotency and the early neural lineage.

  10. geminin acts both like a component of the FGF4 (show FGF4 Proteins) signal transduction pathway that governs trophoblast proliferation and differentiation, and geminin is required to maintain endocycles.

Human Geminin, DNA Replication Inhibitor (GMNN) interaction partners

  1. geminin selectively couples the transcription factor forkhead box O3 (FoxO3 (show FOXO3 Proteins)) to HDAC3 (show HDAC3 Proteins), thereby specifically facilitating FoxO3 (show FOXO3 Proteins) deacetylation.

  2. summarize current information on the molecular functions of Geminin and the regulatory system for Geminin protein expression, and argue for the molecular role of Geminin in cell fate determination of hematopoietic stem cells [review]

  3. Studies indicate that geminin expression is associated with different types of cancer.

  4. High geminin expression is associated with breast cancer.

  5. De novo GMNN mutations cause autosomal-dominant primordial dwarfism associated with Meier-Gorlin syndrome.

  6. Elevated Ki67 (show MKI67 Proteins) and geminin expression distinguish a fraction of metastatic breast carcinoma with worse prognosis.

  7. geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system.

  8. These findings suggest that E2F (show E2F1 Proteins)-mediated activation of Geminin transcription is negatively regulated by Geminin through the inhibition of chromatin remodeling.

  9. Bound Geminin prevents transition of the pre-replicative complexes to a state that is competent for initiation of DNA replication.

  10. Selective expression of geminin during the proliferative phase of the cell cycle and its nuclear specificity increase its potential to be used as an alternative marker of proliferation in breast cancer patients.

Geminin, DNA Replication Inhibitor (GMNN) Protein Profile

Protein Summary

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

Alternative names and synonyms associated with Geminin, DNA Replication Inhibitor (GMNN)

  • geminin-like (LOC100052598)
  • geminin (LOC100351332)
  • CG3183 gene product from transcript CG3183-RA (geminin)
  • geminin, DNA replication inhibitor (gmnn)
  • geminin protein (geminin)
  • geminin, DNA replication inhibitor (GMNN)
  • DyakGE24654-PA (Dyakgeminin)
  • geminin (LOC100049517)
  • geminin (Gmnn)
  • geminin-like (LOC100515035)
  • anon-WO0257455.1 protein
  • AW546347 protein
  • CG3183 protein
  • Dmel\\CG3183 protein
  • Dm geminin protein
  • DyakGE24654 protein
  • dyak_GLEANR_833 protein
  • GB16871 protein
  • GE24654 protein
  • gem protein
  • geminin protein
  • GMNN protein
  • l(2)k14019 protein
  • LOC100049517 protein
  • sb:cb254 protein
  • v(2)k09107 protein
  • zgc:66217 protein

Protein level used designations for GMNN

CG3183-PA , CG3183-PB , geminin-PA , geminin-PB , geminin , geminin protein , geminin, DNA replication inhibitor , DyakGE24654-PA , Dyakgeminin-PA , GE24654-PA

100052598 Equus caballus
100351332 Oryctolagus cuniculus
35563 Drosophila melanogaster
368320 Danio rerio
410093 Apis mellifera
462477 Pan troglodytes
496859 Xenopus (Silurana) tropicalis
708416 Macaca mulatta
6528296 Drosophila yakuba
100049517 Oryzias latipes
57441 Mus musculus
291137 Rattus norvegicus
100515035 Sus scrofa
51053 Homo sapiens
478739 Canis lupus familiaris
526377 Bos taurus
421004 Gallus gallus
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