RNF41 antibody (AA 1-317)
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- Target See all RNF41 Antibodies
- RNF41 (Ring Finger Protein 41 (RNF41))
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Binding Specificity
- AA 1-317
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RNF41 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human, Mouse
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA)
- Isotype
- IgG
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anti-Ring Finger Protein 41 (RNF41) (Internal Region) antibody
RNF41 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, ICC, IF Host: Rabbit Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 255-281), (C-Term) antibodyRNF41 Reactivity: Human WB Host: Rabbit Polyclonal RB38615 unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 218-317) antibodyRNF41 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 1-317) antibodyRNF41 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 218-317) antibodyRNF41 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 4C2 unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 74-123) antibodyRNF41 Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Horse, Monkey, Pig, Hamster WB Host: Rabbit Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 255-281) antibodyRNF41 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- RNF41 (Ring Finger Protein 41 (RNF41))
- Alternative Name
- RNF41 (RNF41 Products)
- Synonyms
- FLRF antibody, NRDP1 antibody, 2210404G21Rik antibody, 4930511A05Rik antibody, 4933415P08Rik antibody, D10Ertd722e antibody, Nrdp1 antibody, wu:fi13f07 antibody, wu:fi25b06 antibody, zgc:55389 antibody, flrf antibody, ring finger protein 41 antibody, ring finger protein 41 S homeolog antibody, ring finger protein 41, E3 ubiquitin protein ligase antibody, RNF41 antibody, Rnf41 antibody, rnf41 antibody, rnf41.S antibody
- Background
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Background: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).
Aliases: 4930511A05Rik antibody, 4933415P08Rik antibody, E3 ubiquitin protein ligase NRDP1 antibody, E3 ubiquitin-protein ligase NRDP1 antibody, Fetal Liver RING finger protein antibody, FLRF antibody, MGC45228 antibody, Neuregulin receptor degradation protein 1 antibody, NRDP1 antibody, RING finger protein 41 antibody, rnf41 antibody, RNF41_HUMAN antibody, SBBI03 antibody
- UniProt
- Q9H4P4
- Pathways
- SARS-CoV-2 Protein Interactome
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