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RNF41 antibody

RNF41 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7118659
  • Target See all RNF41 Antibodies
    RNF41 (Ring Finger Protein 41 (RNF41))
    Reactivity
    • 35
    • 15
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 31
    • 4
    Rabbit
    Clonality
    • 34
    • 1
    Polyclonal
    Conjugate
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RNF41 antibody is un-conjugated
    Application
    • 28
    • 19
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    ring finger protein 41
    Isotype
    IgG
    Top Product
    Discover our top product RNF41 Primary Antibody
  • Application Notes
    WB: 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    RNF41 (Ring Finger Protein 41 (RNF41))
    Alternative Name
    RNF41 (RNF41 Products)
    Synonyms
    FLRF antibody, NRDP1 antibody, 2210404G21Rik antibody, 4930511A05Rik antibody, 4933415P08Rik antibody, D10Ertd722e antibody, Nrdp1 antibody, wu:fi13f07 antibody, wu:fi25b06 antibody, zgc:55389 antibody, flrf antibody, ring finger protein 41 antibody, ring finger protein 41 S homeolog antibody, ring finger protein 41, E3 ubiquitin protein ligase antibody, RNF41 antibody, Rnf41 antibody, rnf41 antibody, rnf41.S antibody
    Background
    Synonyms:FLRF, NRDP1 Background:Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus(By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin(EPO) and interleukin-3(IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages(By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control(PubMed:24949970).
    Molecular Weight
    36 kDa
    Gene ID
    10193
    UniProt
    Q9H4P4
    Pathways
    SARS-CoV-2 Protein Interactome
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