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PIK3C2A antibody (C-Term)

PIK3C2A Reactivity: Human, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6258303
  • Target See all PIK3C2A Antibodies
    PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))
    Binding Specificity
    • 9
    • 7
    • 6
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 40
    • 24
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 38
    • 9
    • 1
    Rabbit
    Clonality
    • 40
    • 8
    Polyclonal
    Conjugate
    • 21
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIK3C2A antibody is un-conjugated
    Application
    • 39
    • 30
    • 21
    • 6
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    PI 3 Kinase Class 2A Antibody detects endogenous levels of total PI 3 Kinase Class 2A.
    Predicted Reactivity
    Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PI 3 Kinase Class 2A, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PIK3C2A Primary Antibody
  • Application Notes
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))
    Alternative Name
    PIK3C2A (PIK3C2A Products)
    Synonyms
    CPK antibody, PI3-K-C2(ALPHA) antibody, PI3-K-C2A antibody, cpk antibody, pi3-k-c2a antibody, Cpk-m antibody, PI3KC2 antibody, sb:cb156 antibody, si:dkey-24l11.7 antibody, wu:fc02a04 antibody, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha antibody, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha antibody, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha S homeolog antibody, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha antibody, PIK3C2A antibody, Pik3c2a antibody, pik3c2a antibody, pik3c2a.S antibody, LOC100548137 antibody
    Background

    Description: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.

    Gene: PIK3C2A

    Molecular Weight
    191 kDa
    Gene ID
    5286
    UniProt
    O00443
    Pathways
    EGFR Signaling Pathway, Inositol Metabolic Process, Platelet-derived growth Factor Receptor Signaling
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