ERCC6 antibody (Internal Region)
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- Target See all ERCC6 Antibodies
- ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ERCC6 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Characteristics
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Rabbit Polyclonal antibody to CSB (excision repair cross-complementing rodent repair deficiency, complementation group 6)
CSB antibody [N2C1], Internal - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human CSB. The exact sequence is proprietary.
- Isotype
- IgG
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- Application Notes
- Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*
- Comment
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Positive Control: 293T , A431 , HeLa , HepG2
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.2 mg/mL
- Buffer
- 1XPBS, 0.2M Tris, 0.2M Glycine, 1 mM EGTA, 50 % Glycerol ( pH 7). 0.025 % ProClin 300 was added as a preservative.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))
- Alternative Name
- CSB (ERCC6 Products)
- Synonyms
- ARMD5 antibody, CKN2 antibody, COFS antibody, COFS1 antibody, CSB antibody, RAD26 antibody, UVSS1 antibody, 4732403I04 antibody, C130058G22Rik antibody, ercc6 antibody, Ercc6 antibody, ERCC excision repair 6, chromatin remodeling factor antibody, excision repair cross-complementing rodent repair deficiency, complementation group 6 antibody, excision repair cross-complementation group 6 antibody, DNA excision repair protein ERCC-6 antibody, ERCC6 antibody, Ercc6 antibody, ercc6 antibody, LOC100719487 antibody
- Background
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This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity, there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B.
Cellular Localization: Nucleus - Molecular Weight
- 168 kDa
- Gene ID
- 2074
- Pathways
- DNA Damage Repair, Chromatin Binding
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