FYN antibody (pTyr530)
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- Target See all FYN Antibodies
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
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Binding Specificity
- pTyr530
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FYN antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Phospho-Fyn (Tyr530) Antibody detects endogenous levels of Fyn only when phosphorylated at Tyr531, which site historically referenced as Tyr530.
- Predicted Reactivity
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human Fyn around the phosphorylation site of Tyr530.
- Isotype
- IgG
- Top Product
- Discover our top product FYN Primary Antibody
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anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibody
FYN Reactivity: Human, Mouse WB, IHC (p), IP, ICC Host: Mouse Monoclonal FYN-01 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) antibodyFYN Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 2A10 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 13-43) antibodyFYN Reactivity: Human, Mouse WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 13-43), (N-Term) antibodyFYN Reactivity: Human, Mouse WB, IHC (p), FACS Host: Rabbit Polyclonal RB03090 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-537) antibodyFYN Reactivity: Human WB, PLA Host: Rabbit Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 7-176) antibodyFYN Reactivity: Human WB, IP, IF, ICC Host: Mouse Monoclonal FYN-01 unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-30) antibodyFYN Reactivity: Human WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (pTyr530) antibodyFYN Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (C-Term) antibodyFYN Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-FYN Oncogene Related To SRC, FGR, YES (FYN) (pTyr530) antibodyFYN Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
- Alternative Name
- FYN (FYN Products)
- Synonyms
- im:6908851 antibody, si:dkey-119m7.5 antibody, zgc:109996 antibody, c-fyn antibody, cfyn-a antibody, SLK antibody, SYN antibody, p59-FYN antibody, PKC antibody, fyn antibody, zgc:86720 antibody, AI448320 antibody, AW552119 antibody, FYN proto-oncogene, Src family tyrosine kinase antibody, FYN proto-oncogene, Src family tyrosine kinase S homeolog antibody, FYN proto-oncogene, Src family tyrosine kinase b antibody, FYN proto-oncogene, Src family tyrosine kinase L homeolog antibody, FYN proto-oncogene, Src family tyrosine kinase a antibody, Fyn proto-oncogene antibody, FYN antibody, fyn.S antibody, fynb antibody, fyn.L antibody, Fyn antibody, fyna antibody
- Background
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Description: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Gene: FYN
- Molecular Weight
- 59kDa
- Gene ID
- 2534
- UniProt
- P06241
- Pathways
- JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
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