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FAM33A antibody (AA 1-121)

FAM33A Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7170591
  • Target See all FAM33A Antibodies
    FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
    Binding Specificity
    • 10
    • 8
    • 6
    • 3
    • 1
    • 1
    AA 1-121
    Reactivity
    • 22
    • 3
    Human
    Host
    • 22
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 9
    • 3
    • 3
    • 3
    • 2
    • 2
    This FAM33A antibody is un-conjugated
    Application
    • 18
    • 17
    • 14
    • 5
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Spindle and kinetochore-associated protein 2 protein (1-121AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:200-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
    Alternative Name
    SKA2 (FAM33A Products)
    Synonyms
    FAM33A antibody, 1110001A07Rik antibody, C78640 antibody, Fam33a antibody, RGD1307084 antibody, fam33a antibody, spindle and kinetochore associated complex subunit 2 antibody, Spindle and kinetochore-associated protein 2 antibody, SKA2 antibody, Ska2 antibody, ska2 antibody
    Background

    Background: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).

    Aliases: FAM33A antibody, Family with sequence similarity 33, member A antibody, FLJ12758 antibody, MGC110975 antibody, Protein FAM33A antibody, SKA 2 antibody, SKA2 antibody, SKA2_HUMAN antibody, Spindle and kinetochore associated complex subunit 2 antibody, Spindle and kinetochore associated protein 2 antibody, Spindle and kinetochore-associated protein 2 antibody, Spindle and KT (kinetochore) associated 2 antibody, Spindle and KT associated 2 antibody

    UniProt
    Q8WVK7
    Pathways
    M Phase
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