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TNFRSF1B antibody (AA 23-257)

TNFRSF1B Reactivity: Human, Mouse WB, ELISA, IHC, FACS, ICC, Neut Host: Mouse Monoclonal 2H11C2 unconjugated
Catalog No. ABIN7193267
  • Target See all TNFRSF1B Antibodies
    TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))
    Binding Specificity
    • 8
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 23-257
    Reactivity
    • 80
    • 57
    • 34
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Mouse
    Host
    • 62
    • 26
    • 11
    • 4
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 55
    • 51
    Monoclonal
    Conjugate
    • 65
    • 16
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This TNFRSF1B antibody is un-conjugated
    Application
    • 67
    • 35
    • 32
    • 30
    • 27
    • 23
    • 19
    • 17
    • 14
    • 9
    • 6
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human CD120B (AA: extra 23-257) expressed in E. coli.
    Clone
    2H11C2
    Isotype
    IgG2b
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: N/A
    Restrictions
    For Research Use only
  • Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))
    Alternative Name
    CD120B (TNFRSF1B Products)
    Synonyms
    CD120b antibody, TBPII antibody, TNF-R-II antibody, TNF-R75 antibody, TNFBR antibody, TNFR1B antibody, TNFR2 antibody, TNFR80 antibody, p75 antibody, p75TNFR antibody, TNF-RII/TNFRSF1B antibody, TNFR-II antibody, TNFRSF1B antibody, TNF-R2 antibody, TNF-alphaR2 antibody, TNFRII antibody, TNFalpha-R2 antibody, Tnfr-1 antibody, Tnfr2 antibody, rank antibody, zgc:163064 antibody, TNF receptor superfamily member 1B antibody, tumor necrosis factor receptor superfamily, member 1b antibody, tumor necrosis factor receptor superfamily, member 1B antibody, TNFRSF1B antibody, Tnfrsf1b antibody, tnfrsf1b antibody
    Background

    Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

    Aliases: TNFRSF1B, p75, TBPII, TNFBR, TNFR2, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II

    Molecular Weight
    48.3 kDa
    Gene ID
    7133
    Pathways
    NF-kappaB Signaling, Apoptosis, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway
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