CHAC1 antibody (AA 43-264)
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- Target See all CHAC1 Antibodies
- CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))
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Binding Specificity
- AA 43-264
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CHAC1 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Glutathione-specific gamma-glutamylcyclotransferase 1 protein (43-264AA)
- Isotype
- IgG
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))
- Alternative Name
- CHAC1 (CHAC1 Products)
- Synonyms
- 1810008K03Rik antibody, RGD1307153 antibody, ChaC glutathione specific gamma-glutamylcyclotransferase 1 antibody, ChaC, cation transport regulator 1 antibody, ChaC glutathione-specific gamma-glutamylcyclotransferase 1 antibody, CHAC1 antibody, Chac1 antibody
- Background
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Background: Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
Aliases: Blocks Notch protein antibody, Botch antibody, Cation transport regulator like protein 1 antibody, Cation transport regulator-like protein 1 antibody, ChaC antibody, ChaC cation transport regulator homolog 1 antibody, ChaC cation transport regulator like 1 antibody, chac1 antibody, CHAC1_HUMAN antibody, Gamma GCT acting on glutathione homolog 1 antibody, Gamma-GCG 1 antibody, Glutathione-specific gamma-glutamylcyclotransferase 1 antibody
- UniProt
- Q9BUX1
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