KREMEN2 Protein (AA 26-364) (His tag)
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- Target See all KREMEN2 Proteins
- KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 26-364
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This KREMEN2 protein is labelled with His tag.
- Purpose
- Human Kremen-2 Protein
- Sequence
- Gly26-Ala364
- Characteristics
- Recombinant Human Kremen-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly26-Ala364.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human Kremen-2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-Kremen-2 Antibody, hFc Tag with the EC50 of 12.4ng/ml determined by ELISA. See testing image for detail.
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Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 26-364) protein (His tag)
KREMEN2 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 25-363) protein (His tag)KREMEN2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 1-420) protein (GST tag)KREMEN2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 121-220) protein (GST tag)KREMEN2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 26-364) protein (His tag)Crystallography grade KREMEN2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 25-363) protein (His tag)Crystallography grade KREMEN2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 26-462) protein (rho-1D4 tag)Crystallography grade KREMEN2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Kringle Containing Transmembrane Protein 2 (KREMEN2) (AA 25-461) protein (rho-1D4 tag)Crystallography grade KREMEN2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Kringle Containing Transmembrane Protein 2 (KREMEN2) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)KREMEN2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))
- Alternative Name
- Kremen-2 (KREMEN2 Products)
- Synonyms
- krm2 Protein, KREMEN2 Protein, MGC147633 Protein, KRM2 Protein, 2900054E04Rik Protein, Krm2 Protein, kringle containing transmembrane protein 2 S homeolog Protein, kringle containing transmembrane protein 2 Protein, kremen2.S Protein, KREMEN2 Protein, kremen2 Protein, Kremen2 Protein
- Background
- Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy.
- Molecular Weight
- 37.1 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
- Pathways
- WNT Signaling
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