SLC26A5 antibody (Internal Region)
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- Target See all SLC26A5 Antibodies
- SLC26A5 (Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SLC26A5 antibody is un-conjugated
- Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- Prestin Antibody detects endogenous levels of total Prestin.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human Prestin, corresponding to a region within the internal amino acids.
- Isotype
- IgG
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anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 351-400) antibody
SLC26A5 Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Monkey, Bat, Pig WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 645-742) antibodySLC26A5 Reactivity: Human ELISA, WB Host: Mouse Monoclonal 1F4 unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (Middle Region) antibodySLC26A5 Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) antibodySLC26A5 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) antibodySLC26A5 Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) antibodySLC26A5 Reactivity: Human, Mouse, Rat, Dog ELISA, WB, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- SLC26A5 (Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5))
- Alternative Name
- SLC26A5 (SLC26A5 Products)
- Synonyms
- pres antibody, fb73d12 antibody, fb74g12 antibody, wu:fb73d12 antibody, wu:fb74g12 antibody, DFNB61 antibody, PRES antibody, Pres antibody, prestin antibody, solute carrier family 26 (anion exchanger), member 5 antibody, solute carrier family 26 member 5 antibody, solute carrier family 26, member 5 antibody, slc26a5 antibody, SLC26A5 antibody, Slc26a5 antibody
- Background
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Description: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
Gene: SLC26A5
- Molecular Weight
- 81 kDa
- Gene ID
- 375611
- UniProt
- P58743
- Pathways
- Sensory Perception of Sound, Dicarboxylic Acid Transport
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