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CH25H antibody (AA 142-272)

CH25H Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7147600
  • Target See all CH25H Antibodies
    CH25H (Cholesterol 25-Hydroxylase (CH25H))
    Binding Specificity
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 142-272
    Reactivity
    • 11
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 9
    • 3
    Rabbit
    Clonality
    • 10
    • 2
    Polyclonal
    Conjugate
    • 8
    • 2
    • 1
    • 1
    This CH25H antibody is un-conjugated
    Application
    • 8
    • 5
    • 3
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Cholesterol 25-hydroxylase protein (142-272AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CH25H (Cholesterol 25-Hydroxylase (CH25H))
    Alternative Name
    CH25H (CH25H Products)
    Synonyms
    CH25H antibody, zgc:101688 antibody, MGC143045 antibody, C25H antibody, AI462618 antibody, m25OH antibody, cholesterol 25-hydroxylase antibody, cholesterol 25-hydroxylase L homeolog antibody, CH25H antibody, ch25h antibody, Ch25h antibody, ch25h.L antibody
    Background

    Background: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

    Aliases: CH25H antibody, Cholesterol 25-hydroxylase antibody, EC 1.14.99.38 antibody, Cholesterol 25-monooxygenase antibody, h25OH antibody

    UniProt
    O95992
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