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Ectopic overexpression of Bombyx mori Asparagine synthetase (BmASNS) gene effectively inhibited cell growth in silkworm cells, whereas its overexpression could rescue cell growth upon amino acid deprivation treatment.
Asns is involved in the regulation of plasma glucose levels.
Transient knockdown of ASNS inhibited cell proliferation and colony formation in AGS (show JAG1 ELISA Kits) and MKN-45 cells. Stable knockdown of ASNS conferred sensitivity to cisplatin in these cells. Depletion of ASNS and cisplatin treatment exerted synergistic effects on tumor growth in AGS (show JAG1 ELISA Kits) xenografts. Moreover, ASNS was found to be up-regulated in human gastric cancer tissues compared with matched normal colon tissues.
role of ASNS in melanoma cells A375 and human epidermoid carcinoma cell line A431
Polymorphisms of ASNS are associated with an increased risk of asparaginase-related complications in children with acute lymphoblastic leukemia.
Data shows that high ASNS expression in NK/T cell lymphoma is correlated with worse clinicopathological features.
ASNS deficiency is correlated with poor therapeutic response and worse survivals in patients with rectal cancer receiving neoadjuvant CCRT
cell differentiation was enhanced when asparagine in the culture media was depleted by an addition of L-asparaginase (show ASRGL1 ELISA Kits), indicating that downregulation of asparagine synthetase gene expression
ASNS and MMP19 (show MMP19 ELISA Kits), along with eIF3a (show EIF6 ELISA Kits), are the sensitivity factors for cisplatin treatment and may serve as potential candidate molecular markers for predicting cisplatin sensitivity of advanced nasopharyngeal carcinoma.
A conditional interaction between the ASNS polymorphism and an early response to chemotherapy among pediatric patients with acute lymphoblastic leukemia.
expression of ASNS was higher in hepatocellular carcinoma tissues; expression of ASNS is an independent factor affecting the survival of HCC (show FAM126A ELISA Kits) patients, and low ASNS expression in HCC (show FAM126A ELISA Kits) was correlated with worse surgical outcomes
Identifying the roles of ASNS in fetal development, tissue differentiation, and tumor growth may reveal that ASNS function extends beyond asparagine biosynthesis.
ASN1-encoded asparagine synthetase in floral organs contributes to nitrogen filling in Arabidopsis seeds
bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene.
, Asparagine synthetase
, asparagine synthetase [glutamine-hydrolyzing]
, glutamine-dependent asparagine synthetase
, TS11 cell cycle control protein
, Glutamine-dependent asparagine synthetase
, asparagine synthetase 1