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anti-Mouse (Murine) PDIA6 Antibodies:
anti-Human PDIA6 Antibodies:
anti-Rat (Rattus) PDIA6 Antibodies:
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Human Monoclonal PDIA6 Primary Antibody for ELISA, WB - ABIN2752398
Lee, Min Kim, Dotimas, Li, Feener, Baldus, Myers, Chutkow, Patwari, Yoshioka, Lee: Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress. in EMBO molecular medicine 2014
one additional protein, namely P58 (show CDK11B Antibodies)(IPK), specifically precipitated with Akita proinsulin (show INS Antibodies) and approximately ten fold more PDIA6, but not other PDI (show PDIA3 Antibodies) family members, was bound to Akita proinsulin (show INS Antibodies). The latter suggests that PDIA6 may act as a key reductase
these findings demonstrated that ER Ca2 (show CA2 Antibodies)+, PDIA6, IRE1alpha (show ERN1 Antibodies), and miR (show MLXIP Antibodies)-322 function in a dynamic feedback loop modulating the UPR under conditions of disrupted ER Ca2 (show CA2 Antibodies)+ homeostasis.
By facilitating disulfide bond formation, and enhanced ER protein folding, PDIA6 may contribute to the protective effects of ATF6 (show ATF6 Antibodies) in the ischemic mouse heart.
Downregulation of PDIA6 inhibited BC cell proliferation and invasion in vitro as well as tumor growth and metastasis in vivo. In addition, PDIA6 downregulation suppressed the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
Results indicate that re-expression of miR (show MLXIP Antibodies)-127-3p and miR (show MLXIP Antibodies)-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 (show UBXN11 Antibodies) and PDIA6.
ACE (show ACE Antibodies) and PDIA6 were identified as potential HSPA2 (show HSPA2 Antibodies)-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri (show PLIN1 Antibodies)-acrosomal region of the sperm head.
Restoration of miR (show MLXIP Antibodies)-127-3p and miR (show MLXIP Antibodies)-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1 (show UBXN11 Antibodies), GLE1 (show GLE1 Antibodies) and PDIA6.
PDIA3 (show PDIA3 Antibodies) and PDIA6 gene expression is a neoplasm aggressiveness marker in primary ductal breast cancer.
CDDP-resistant non-small lung cancer cells undergo profound remodeling of their endoplasmic reticulum (ER) proteome (>80 proteins identified by proteomics) and exhibit a dramatic overexpression of two protein disulfide isomerases, PDIA4 (show PDIA4 Antibodies) and PDIA6.
Txnip (show TXNIP Antibodies) is located in the endoplasmic reticulum and interacts with endogenous PDIA6. Txnip (show TXNIP Antibodies) increases PDI (show PADI1 Antibodies) activity.
levels of expression of ERp5 and GRP78 (show HSPA5 Antibodies) correlated with the level of expression of membrane-bound MICA (show MICA Antibodies) in chronic lymphocytic leukemia patients.
Data show that the lymph node (LN) stroma displayed in situ high levels of transcription and expression of the disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase (show ADAM17 Antibodies) ADAM10 (show ADAM10 Antibodies), able to shed the ligands for NKG2D (NKG2D (show KLRK1 Antibodies)-L) from the cell membrane.
P5 forms a non-covalent complex with immunoglobulin heavy chain binding protein (BiP (show HSPA5 Antibodies)) and shows specificity towards BiP (show GDF10 Antibodies) client proteins.
Protein disulfide isomerases (EC 22.214.171.124), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995
protein disulfide isomerase-related protein
, protein disulfide-isomerase A6
, thioredoxin domain containing 7
, thioredoxin domain-containing protein 7
, ER protein 5
, endoplasmic reticulum protein 5
, protein disulfide isomerase P5
, protein disulfide isomerase-associated 6
, thioredoxin domain containing 7 (protein disulfide isomerase)
, calcium-binding protein 1
, protein disulfide isomerase A6
, protein disulfide isomerase associated 6