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Results highlighted the essential roles played by GADD34 (show PPP1R15A Antibodies) and CReP in regulating mRNA translation during unstressed conditions and following endoplasmic reticulum stress.
CReP expression was markedly suppressed in XBP1 (show XBP1 Antibodies)-deficient mice livers due to hyperactivated Ire1alpha (show ERN1 Antibodies).
Ppp1r15a (show PPP1R15A Antibodies) mutant mice are superficially indistinguishable from wild type; Ppp1r15b(-/-) mouse embryos survive gestation but exhibit severe growth retardation and impaired erythropoiesis, and loss of both Ppp1r15 genes leads to early embryonic lethality
Whole-exome sequencing identified a homozygous missense mutation, c.1972G>A; p.Arg658Cys, in protein phosphatase 1 (show PPP1CB Antibodies), regulatory subunit 15b (PPP1R15B)
the first homozygous mutation in the PPP1R15B gene encoding the regulatory subunit of an eIF2alpha (show EIF2A Antibodies)-specific phosphatase in two siblings affected by a novel syndrome of diabetes of youth with short stature, intellectual disability, and microcephaly
CIP2A (show KIAA1524 Antibodies) regulates cancer metabolism and CREB (show CREB1 Antibodies) phosphorylation in non-small cell lung cancer
the mammalian traffic machinery co-opts p-eIF2alpha (show EIF2A Antibodies) and CReP, regulators of translation initiation.
PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1\; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009
constitutive repressor of eIF2alpha phosphorylation
, protein phosphatase 1 regulatory subunit 15B
, protein phosphatase 1, regulatory (inhibitor) subunit 15B
, protein phosphatase 1, regulatory (inhibitor) subunit 15b