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Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed.
The N-terminal domain of Ago3 inhibits cleavage activity. AAs (show FGD1 Antibodies) 1-64 are largely unstructured & form a large loop surrounding an area containing two helices & another unstructured loop.
The Ago3 PIWI (show PIWIL1 Antibodies) domain is slicing competent but our Ago3 model suggests multiple interactions between residues in the PIWI (show PIWIL1 Antibodies) & N domains that may increase protein rigidity or invoke other properties that contribute to Ago3's observed slicing deficiency.
DICER (show DICER1 Antibodies)- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation.
Ago3 is able to load microRNAs efficiently in the absence of Ago1 (show EIF2C1 Antibodies) and Ago2 (show EIF2C2 Antibodies), despite a significant loss of global microRNA expression
reliable predictions of miRNA affinity to Ago2 (show EIF2C2 Antibodies) AND Ago3 proteins were made.
The specificity of RNA interference depends on the concentration of Ago1 (show EIF2C1 Antibodies), Ago3, and Ago4 (show EIF2C4 Antibodies) relative to Ago2 (show EIF2C2 Antibodies).
EIF@C3 protein (show RPS3A Antibodies) is expressed in both Schwann and neuron-type differentiating cells.
Results from the liver show that, siRNA targets 3'UTR (show UTS2R Antibodies) and the coding sequence (CDs (show ABHD5 Antibodies)) of endogenous genes in the presence Ago2 (show EIF2C2 Antibodies) but in its absence, only 3'UTR (show UTS2R Antibodies)-targeted siRNA-mediated knockdown are active with the help of Ago1 (show EIF2C1 Antibodies) and Ago3.
enhanced flu susceptibility of Ago1 (show EIF2C1 Antibodies)/3 double-knockout mice arises from an intrinsic impairment in the ability of lung cells to tolerate flu-elicited inflammation.
EIF2C2 (show EIF2C2 Antibodies)-4 and PIWIL4 (show PIWIL4 Antibodies) appear increased in advanced tumors with distant metastasis, suggesting they may promote tumor invasion
Data show that Ago4 (show EIF2C4 Antibodies)- Ago1 (show EIF2C1 Antibodies)-Ago3 genes are linked together at the p12 (show SPRN Antibodies) of the chromosome 6, while Ago2 (show EIF2C2 Antibodies) is located at the p15 (show CDKN2B Antibodies) of the chromosome 4.
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
, eIF-2C 3
, eIF2C 3
, eukaryotic translation initiation factor 2C, 3
, protein argonaute-3
, argonaute 3b
, argonaute RISC catalytic component 3
, eukaryotic translation initiation factor 2C, 3b
, Piwi/Argonaute family protein meIF2C3
, eukaryotic translation initiation factor 2C 3