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Browse our LCK Proteins (LCK)

Full name:
Lymphocyte-Specific Protein tyrosine Kinase Proteins (LCK)
On www.antibodies-online.com are 11 Lymphocyte-Specific Protein tyrosine Kinase (LCK) Proteins from 8 different suppliers available. Additionally we are shipping LCK Antibodies (387) and LCK Kits (18) and many more products for this protein. A total of 438 LCK products are currently listed.
Synonyms:
Hck-3, LCK, Lck1, Lcktkr, LSK, Lskt, p56, P56LCK, pp58lck, tkl, YT16, zgc:136695
list all proteins Gene Name GeneID UniProt
LCK 16818 P06240
LCK 3932 P06239
Rat LCK LCK 313050 Q01621

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LCK Proteins (LCK) by Origin

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Top referenced LCK Proteins

  1. Human LCK Protein expressed in Baculovirus infected Insect Cells - ABIN2001955 : Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ... in Cell 2007 (PubMed)
    Show all 2 references for ABIN2001955

More Proteins for LCK Interaction Partners

Mouse (Murine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. Aurora A (show AURKA Proteins) inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A (show AURKA Proteins) is required for maintaining Lck active during T-cell activation.

  2. essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells

  3. Lck-Dlx5 (show DLX5 Proteins) mice develop T-ALLs that consistently acquire overexpression of Myc (show MYC Proteins) and activation of Akt (show AKT1 Proteins).

  4. Lck-CD8 (show CD8A Proteins) interaction is required for initial CD8 (show CD8A Proteins) recruitment.

  5. The kinase Itk (show ITK Proteins) and the adaptor TSAd (show SH2D2A Proteins) change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

  6. CD4 (show CD4 Proteins) is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase (show YES1 Proteins) p56lck

  7. Study concludes that the intracellular state of Lck Study conclude that the intracellular state of Lck determines the specificity of thymic selection and that Lck association with coreceptor proteins during thymic selection is the mechanism by which MHC restriction is imposed on a randomly generated alphabetaTCR repertoire.

  8. LCK could be considered a target attenuated by the anti-aging effects of CR. Integrative analysis of cDNA microarray and interactome data are powerful tools for identifying target molecules that are involved in the aging process and modulated by CR.

  9. Mechanistically, poly-G oligonucleotides directly induce the phosphorylation of Lck (an essential element of the T cell-signaling pathway), thereby enhancing production of IL-2 (show IL2 Proteins) and CD8 (show CD8A Proteins) T cell proliferation.

  10. Specific pharmacological inhibition and genetic silencing indicated the involvement of Lck in the regulation of neuritic outgrowth.

Human Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. Aurora A (show AURKA Proteins) inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A (show AURKA Proteins) is required for maintaining Lck active during T-cell activation.

  2. Results demonstrate that Lck represses oxidative phosphorylation through competitive binding with mitochondrial CRIF1 (show GADD45GIP1 Proteins) in a kinase-independent manner.

  3. introducing bulky side-chains into this patch (GGxxG to GVxxL) impairs the Lck-independent role of CD4 in T cell activation upon TCR engagement of agonist and weak agonist stimulation.

  4. our results support a novel function of nuclear Lck in promoting human leukemic T cell survival through interaction with a tumor suppressor, CRIF1 (show GADD45GIP1 Proteins)

  5. TSAD (show SH2D2A Proteins) binds to and co-localizes with Nck (show NCK1 Proteins). Expression of TSAD (show SH2D2A Proteins) increases both Nck (show NCK1 Proteins)-Lck and Nck (show NCK1 Proteins)-SLP-76 (show LCP2 Proteins) interaction in T cells.

  6. These findings demonstrate highly dynamic Lck palmitoylation kinetics that are essential for signaling downstream of the Fas receptor (show FAS Proteins).

  7. Cells from PAX5 (show PAX5 Proteins) translocated patients show LCK up-regulation and over-activation, as well as STAT5 (show STAT5A Proteins) hyper-phosphorylation, compared to PAX5 (show PAX5 Proteins) wt and PAX5 (show PAX5 Proteins) deleted cases.

  8. T cell receptor (TCR)-CD3 (show CD3 Proteins) complex and the Lck kinase were required for Ca(2 (show CA2 Proteins)+) mobilization but not for apoptosis induction in Jurkat cells.

  9. In T-cells, cholesterol-dependent domains function in the regulation of the Src (show SRC Proteins) family kinase Lck (p56lck) by sequestering Lck from its activator CD45 (show PTPRC Proteins). (Review)

  10. The kinase Itk (show ITK Proteins) and the adaptor TSAd (show SH2D2A Proteins) change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

Pig (Porcine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. LCK gene could be an useful candidate gene in selection for increasing litter size in pigs.

LCK Protein Profile

Protein Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.

Alternative names and synonyms associated with LCK

  • lymphocyte-specific protein tyrosine kinase (lck)
  • lymphocyte-specific protein tyrosine kinase (LCK)
  • lymphocyte-specific protein tyrosine kinase (LOC100349102)
  • lymphocyte protein tyrosine kinase (Lck)
  • lymphocyte-specific protein tyrosine kinase (Lck)
  • Hck-3 protein
  • LCK protein
  • Lck1 protein
  • Lcktkr protein
  • LSK protein
  • Lskt protein
  • p56 protein
  • P56LCK protein
  • pp58lck protein
  • tkl protein
  • YT16 protein
  • zgc:136695 protein

Protein level used designations for LCK

lymphocyte protein tyrosine kinase , lymphocyte-specific protein tyrosine kinase , tyrosine-protein kinase Lck-like , leukocyte C-terminal Src kinase , lymphocyte cell-specific protein-tyrosine kinase , proto-oncogene tyrosine-protein kinase LCK , T-lymphocyte specific protein tyrosine kinase p56lck , p56(LSTRA) protein-tyrosine kinase , t cell-specific protein-tyrosine kinase , tyrosine-protein kinase Lck , tyrosine protein kinase , tyrosine-protein kinase LCK , p56-LCK

GENE ID SPECIES
414333 Danio rerio
456715 Pan troglodytes
100216439 Ovis aries
100349102 Oryctolagus cuniculus
100436326 Pongo abelii
100477981 Ailuropoda melanoleuca
16818 Mus musculus
3932 Homo sapiens
396460 Gallus gallus
313050 Rattus norvegicus
478151 Canis lupus familiaris
100233188 Sus scrofa
508890 Bos taurus
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