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TRIM proteins trim the balance of homoeostasis by modulating various biological pathways through protein-protein interactions.
MG53/TRIM72 (show TRIM72 Proteins) protein can be directly applied as a therapeutic agent to increase membrane repair capacity of many cell types.
TRIM acts to chaperone CTLA-4 (show CTLA4 Proteins) transport to the cell surface; this function would be required to account for the phenotypic and functional properties of CD8 (show CD8A Proteins)(+) Tregs.
TRIM is dispensable for T-cell development and peripheral immune functions.
TRIM and Src homology domain-containing tyrosine phosphatase 2-interacting transmembrane adaptor protein (SIT) regulate cell fate of developing thymocytes and are essential regulators of central tolerance.
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells (By similarity).
T cell receptor associated transmembrane adaptor 1
, T cell receptor interacting molecule
, T-cell receptor interacting molecule
, T-cell receptor-associated transmembrane adapter 1
, T-cell receptor-interacting molecule