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Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 (show CD74 Proteins) by SPPL2a (show SPPL2A Proteins).
In human B cells, SPPL2a (show SPPL2A Proteins) is indispensable for turnover of CD74 (show CD74 Proteins) N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a (show SPPL2A Proteins) transcript and protein.
Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a (show SPPL2A Proteins)).
concluded that IMPAD1 should be screened for patients with Catel-Manzke and additional features
Data show that endogenous SPPL2a (show SPPL2A Proteins) - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.
Affected individuals carried homozygous missense mutations in IMPAD1, the gene coding for gPAPP, a Golgi-resident nucleotide phosphatase that hydrolyzes phosphoadenosine phosphate (PAP (show REG3A Proteins)), the byproduct of sulfotransferase reactions, to AMP (show APRT Proteins).
SPP, SPPL2a (show SPPL2A Proteins), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis
ADAM10 (show ADAM10 Proteins) and SPPL2a (show SPPL2A Proteins) were identified as two proteases implicated in FasL (show FASL Proteins) processing and release of the FasL (show FASL Proteins) intracellular domain, which has been shown to be important for retrograde FasL (show FASL Proteins) signaling
SPPL2a (show SPPL2A Proteins) and SPPL2b (show SPPL2B Proteins) mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (show ITM2B Proteins) N-terminal fragment.
Golgi plays an important role in glycosaminoglycan sulfation and define a function for gPAPP in the formation of skeletal elements derived through endochondral ossification[3'-phosphoadenosine 5'-phosphate phosphatase]
identify JAWS as a key regulator of chondrogenesis and synovial joint positioning required for the restriction of joint formation to discrete stereotyped locations in the embryonic skeleton
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.
inositol monophosphatase domain containing 1
, myo-inositol monophosphatase A3
, inositol monophosphatase 3
, inositol monophosphatase 3-like
, Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase
, IMPase 3
, golgi-resident PAP phosphatase
, inositol monophosphatase domain-containing protein 1
, inositol-1(or 4)-monophosphatase 3
, Golgi-resident PAP phosphatase
, IMP 3
, Inositol monophosphatase domain-containing protein 1
, Inositol-1(or 4)-monophosphatase 3
, Myo-inositol monophosphatase A3
, SPP-like 2A
, intramembrane cleaving protease
, intramembrane protease 3
, presenilin-like protein 2
, signal peptide peptidase-like 2A